医院中药不良反应报告分析

Adverse drug reactions of traditional Chinese medicine

目的对中药不良反应报告进行分析，归纳总结药品不良反应（ADR）形成的原因特点及规律，促进中药合理使用。方法收集北京中医药大学附属护国寺中医医院2011年1月至2013年12月3年上报的中药不良反应报告共58例，对ADR报表中患者的性别、年龄、给药途径、药物种类、累及系统、临床表现等情况进行统计和分析。结果女性患者发生ADR为41例，占70．7％，男性发生ADR为17例，占29．3％，70岁以上老年患者发生ADR为27例，占46．6％；中药注射剂单独使用或与西药注射剂联合使用引起的ADR46例，占ADR报告总数的79．3％。结论女性患者ADR构成比均高于男性患者，70岁以上老年患者为ADR易发人群；中药注射剂较其他剂型更易发生不良反应。应重视中药ADR监测和上报工作，药剂科应加强与临床科室合作，并肩携手促进合理用药，保障患者用药安全。

Objective To analyze adverse drug reactions （ADR） of traditional Chinese medicine. Methods A total of 58 cases of ADR reports, between January 2011 and December 2013 were collected; gender, age, administration route, types of drug, involved systems and clinical features were analyzed. Results There were 41 female patients suffering from ADR, with the proportion of 70.7% ; 17 male patients were with proportion of 29.3%. There were 27 patients over the age of 70 years and the proportion was 46.6%. The ADR events devel- oped in 46 patients by traditional Chinese medicine injection alone or combined with western medicine injection; the proportion was 79.31%. Conclusions The ADR occurrence rate in the female patients is higher than that in male patients. Patients over 70 years have more ADR than others.