ESR、RF、抗CCP和AKA联合检测对类风湿性关节炎的诊断价值

The Value of Combined Detection of ESR,RF,Anti CCP and AKA in the Diagnosis of Rheumatoid Arthritis

目的:探讨红细胞沉降率(ESR)、类风湿因子(RF)、抗环瓜氨酸多肽抗体(抗CCP)和抗角蛋白抗体(AKA)联合检测对类风湿性关节炎(RA)的临床诊断价值。方法:对100例RA患者和70例非RA的其他自身免疫病患者检测ESR、RF、抗CCP和AKA四种指标。结果:RA患者组的四项检查阳性率均明显高于其他自身免疫病组,单项检测RA诊断的敏感性为ESR>RF>抗CCP>AKA,特异性抗CCP>AKA>RF>ESR,联合检测对RA诊断的敏感性下降,特异性却升高甚至高达100%。结论:ESR、RF、抗CCP和AKA联合检测可提高对RA诊断的特异性,对RA的早期诊断有较高价值。

Objective：To investigate the clinical value of combined detection of erythrocyte sedimentation rate （ESR）,rheumatoid factor（RF）,anti-cyclic citrullinated peptide antibody（anti CCP） and anti keratin antibody （AKA） in diagnosis of rheumatoid arthritis（RA）.Method： ESR, RF, anti CCP and AKA in 100 patients with RA and 70 patients with other autoimmune diseases were detected.Result： In RA group, positive rate of four indexs was obviously higher than those of other autoimmune disease group, individual testing RA diagnostic sensitivity for ESR〉RF〉CCP〉AKA, the specificity of CCP〉AKA〉RF〉ESR,combined detection of RA diagnostic sensitivity,specificity was elevated even higher amounts to 100%.Conclusion：Combined detection of ESR,RF,anti CCP and AKA can improve RA diagnostic specificity,has high value on early diagnosis of RA.