奥美拉唑联合莫沙必利治疗反流性食管炎临床分析

Clinical Analysis of Omeprazole Combined with Mosapride in the Treatment of Reflux Esophagitis

目的:探讨奥美拉唑联合莫沙必利治疗反流性食管炎的临床效果。方法:选取笔者所在医院收治的536例反流性食管炎患者,按照随机数字表法分为观察组和对照组,各268例,两组均使用奥美拉唑治疗,观察组在此基础上加用莫沙必利治疗,疗程为4周,治疗结束后观察两组患者的临床疗效及不良反应情况。结果:观察组显效242例,有效16例,无效10例,总有效率96.27%(258/268);对照组显效213例,有效13例,无效42例,总有效率84.33%(226/268),两组比较差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:奥美拉唑联合莫沙必利治疗反流性食管炎临床疗效优于单一用药,且不增加药物不良反应,值得临床推广。

Objective：To investigate the clinical effect of Omeprazole combined with Mosapride in the treatment of reflux esophagitis.Method：536 cases of reflux esophagitis patients were randomly divided into the observation group and the control group,268 cases in each group,two groups were treated with Omeprazole,the observation group on the basis of the treatment with Mosapride,course of treatment for 4 weeks,the clinical efficacy and adverse reactions of two groups were observed.Result：The observation group,excellent 242 examples, effective 16 examples, invalid 10 examples,the total effectiveness was 96.27%（258/268）.The control group,excellent 213 examples,effective 13 examples,invalid 42 examples,the total effectiveness was 84.33%（226/268）,there was statistical significance（P〈0.05）.Incidences of adverse effect showed no significant difference between the treatment and the control groups（P〉0.05）.Conclusion：Omeprazole combined with Mosapride in the treatment of reflux esophagitis,clinical curative effect is superior to the single drug,and no increase in adverse drug reactions,is worthy of clinical promotion.