狼疮性肾炎尿毒症采用强化免疫干预在临床治疗中的效果研究

Clinical Effect of Enhanced Immune Intervention in the Treatment of Uremia with Lupus Nephritis

目的:分析强化免疫干预治疗狼疮性肾炎尿毒症的疗效。方法:选取2007年2月-2013年7月于笔者所在医院住院的狼疮性肾炎尿毒症患者40例,患者首先进行腹膜透析或血液透析,尿毒症的症状改善后以IVMP进行治疗,继续长疗程使用IVCTX冲击方案与强的松标准疗程。结果:经治疗后,肾功能可逆的缓解者20例,狼疮性肾炎病程在两年以内的有22例,其中15例肾功能得到缓解,17例狼疮性肾炎病程在两年以上的患者中,仅4例得到可逆缓解,1例肾功能长达两年保持稳定。4例分别在脱离透析以后的6、8、15和60个月后尿毒症复发。结论:狼疮性肾炎尿毒症防感染和早期的积极治疗尤为重要,免疫球蛋白静脉输入可加强抗病毒抗感染的效应,又能够经由免疫干预和溶解肾组织所沉积的具有免疫功能的复合物来治疗狼疮性的肾炎。

Objective：To analyze the curative effect of enhanced immune intervention in the treatment of uremia with lupus nephritis. Method：From February 2007 to July 2013 hospitalized in our hospital 40 uremic patients with lupus nephritis were selected,patients first were given peritoneal dialysis and hemodialysis,uremia symptoms improved after treatment with IVMP,continue long treatment used standard IVCTX impact with prednisone treatment.Result：After treatment,the kidney function reversible ease in 20 cases,lupus nephritis in 22 cases within two years,including 15 cases of renal function,duration of 17 patients with lupus nephritis in patients with more than two years of reversible only 4 cases of relief,1 case of renal function remained stable for up to two years.4 cases respectively after dialysis from 6,8,15 and 60 months after recurrence.Conclusion：Uremia with lupus nephritis infection prevention and early treatment are very important to actively,can strengthen the antiviral immune globulin intravenous input antibacterial effect,and can be dissolved by immune intervention and renal tissue deposition by which has the function of immune complex treating lupous nephritis.