上海体检人群胃蛋白酶原水平及与幽门螺杆菌感染的相关性

Study of correlation between pepsinogen levels and Helicobacterpylori infection among people taking physical examination in Shanghai

目的 分析上海地区健康体检人群血清胃蛋白酶原（PG）水平的分布,并探讨其与幽门螺杆菌（Hp）感染的关系.方法 采用透射免疫比浊法和C13尿素呼气试验（UBT）对健康体检人群进行调查,了解人群血清PGⅠ和PGⅡ含量和胃Hp感染情况.结果 调查8 763人的血清PG Ⅰ 、PGⅡ及PG Ⅰ/PGⅡ呈偏态分布,男性均高于女性,人群Hp感染率为38.23％;Hp阴性组PGⅠ、PGⅡ和PGⅠ/PGⅡ的95％分布区间分别为：男性26.2～ 108.5 μg/L、5.1～ 22.9 μg/L和≥3.47;女性22.3～ 79.1μg/L、4.6～ 18.8 μg/L和≥3.37.＞50岁组PG Ⅰ、PGⅡ有上升趋势,而PGⅠ/PGⅡ呈下降趋势;Hp阳性组血清PGⅠ、PGⅡ及PGⅠ/PGⅡ阳性率高于Hp阴性组,差异均有统计学意义（P值均＜0.01）.结论 血清PGⅠ、PGⅡ水平与性别、年龄及Hp感染相关,了解人群血清PG水平的分布,有助于对胃相关疾病的判断.

Objective To analyze serum pepsinogen levels of people taking physical examination in Shanghai and study its correlation with Helicobacter pylori （Hp）infection. Methods Transmission immune turbidimetry method and C13 urea breath test（UBT） were used to detect the helicobacter pylori （Hp）infection and serum PGI and PGII levels in normal people taking physical examination. Results A total of 8 763 subjects were examined, serum PG Ⅰ , PG Ⅱ and PG Ⅰ/PG Ⅱ levels showed a skewed distribution, males showed higher levels than females. Overall Hp infection rate of normal people was 38.23% . For Hp negative group, 95% of PGⅠ ,PGⅡ and PG Ⅰ/PG Ⅱ were distributed in range of 26.2N 108.5 μg/L, 5.1- 22.9μg/L,≥ 3.47 for males and 22.3-- 79.1 μg/L、4.6-18.8 μg/L,≥3.37 for females. For people〉 50 years old, serum PGⅠ and PG Ⅱ levels demonstrated an ascending trend, while PG Ⅰ/PG Ⅱ showed a descending trend . For Hp-infected group, serum PGI, PGⅡ levels and PG Ⅰ/PG Ⅱ were higher than those of Hp negative group , with significant differences （all P 〈 0.01 ） . Conclusion Serum PGⅠ,PGⅡ levels were correlated with gender, age, and Hp infection. Understanding of the distribution of serum PG levels contributes to diagnosis for stomach related diseases.