普伐他汀相关肌病不良反应的研究进展

Research progress on adverse reactions of pravastatin-associated myopathy

目的对普伐他汀导致相关肌病不良反应的最新研究进展进行简要综述,探讨普伐他汀在临床上的合理应用及肌病不良反应的防治措施。方法检索EMbase、万方数据库、中国生物医学文献数据库中相关文献,结合临床,进行综合分析。结果普伐他汀可致相关性肌病、疲倦和劳力性疲劳等不良反应。结论制定普伐他汀的合理用药方案,最大限度地发挥其降脂疗效,减少肌病等不良反应的发生。

Objective To briefly reviewthe latest research progress about adverse reactions of pravastatin related myopathy,investigate the reasonable application of pravastatin in the clinical and prevention measures of myopathy adverse reactions. Methods The EMbase,Wanfang database,China biomedical literature database of relevant literatures were retrieved,and the results were comprehensively analyzed combined with clinical. Results Pravastatin can cause related myopathy,tired and exertional fatigue and other adverse reactions. Conclusion Rational use of pravastatin can maximize its lipid-lowering effect,reduce the occurrence of adverse reactions such as myopathy.