511例颈动脉粥样硬化患者不同中医证型间血脂及胰岛素敏感指数的比较

Research on serum lipid and insulin sensitivity index of different patterns of traditional Chinese medicine in 511 patients with carotid atherosclerosis

[目的]探讨颈动脉粥样硬化的中医临床常见证型间相关生化指标是否存在差异性。[方法]采集511例颈动脉粥样硬化患者中医证候,检测全套血脂、空腹血糖、空腹胰岛素,经多元统计学分析得出临床常见证型,比较不同证型间检测实验室指标的差异性。[结果]肝肾阴虚型血清极低密度脂蛋白胆固醇(VLDL-C)均值最高,其次为肾虚气滞型。肾虚气滞型APOB均值最高,其次为肾虚痰浊型。血清甘油三酯(TG)、血清总胆固醇(TC)、血清高密度脂蛋白胆固醇(HDL-C)、血清低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A(APOA)、脂蛋白(a)[LP(a)]、空腹血糖(FPG)、空腹胰岛素(FIN)、胰岛素敏感指数(ISI)无组间差异性(P>0.05)。[结论]各证型间VLDL-C、APOB差异有统计学意义(P<0.05)。

[Objective] Try to find the differences of relative critical factors between types of carotid atherosclerosis＇s disease traditional Chinese medicine （TCM） syndromes. [Methods] Through document reference and expert consultation, get the form of carotid atherosclerosis＇s disease syndrome of TCM. By clinical epidemiological investigation, TCM syndrome distribution characteristics and the relative factors of 511 patients with carotid atherosclerosis were observed, determinate the blood lipids, FPG, INS. Factor analysis, clustering analysisfrequency advantage analysis and golden section analysis were adopted to analyse the clinical data of 511 cases of carotid atherosclerosis＇s disease. Compare the relative factors in different types of TCM clinical syndromes with statistic methods. [Results] The differences between six types in blood indexs： mean of VLDL-C,APOB in insufficiency of liver Yin and kidney Yin type is the highest. Insufficiency of kidney essence and Qi stagnation type is the second. Mean of APOB in insufficiency of kidney essence and Qi stagnation type is the highest, while insufficiency of kidney essence and phlegm type is the second.There is no statistical differences in TG, TC, HDL-C, LDL-C, APOA, LP （a）, FPG, FIN, ISI, among these six TCM types （P〉0.05）. [Conclusion] There is statistical differences inVLDL-C between these six TCM types.