摘要
目的 评价替吉奥(S-1)联合紫杉醇周疗治疗晚期老年胃癌患者的近期疗效及毒副反应物.方法 将广西横县人民医院确诊的38例晚期老年胃癌患者随机分为2组,治疗组20例,采用紫杉醇联合替吉奥化疗:紫杉醇60 mg/m2,第1、8、15 d用药,替吉奥胶囊80 mg/m2,2次/d,连续口服14 d,28 d为1个周期;对照组18例,采用FP方案:顺铂15 mg/m2,第1~5天静点,5-Fu 750mg/m2,第1~5天静点,28 d为1个周期.两组患者至少治疗2个周期后评价其疗效及毒副反应.结果 治疗组与对照组的有效率(RR)、疾病控制率(DCR)、1年生存率分别为40.0%、75.0%、55.0%和22.2%、50.0%、38.9%,差异无统计学意义(P>0.05);治疗组患者KPS改善情况优于对照组(P<0.05);治疗组的胃肠道反应及Ⅲ~Ⅳ度骨髓抑制明显低于对照组(P<0.05).结论 替吉奥口服联合紫杉醇周疗方案化疗有效率高,老年患者耐受性好,是老年晚期胃癌患者值得选择的化疗方案.
Objective To evaluate the efficacy and toxicity of S-1 capsule combined with weekly Paclitaxel on elder- ly patients with advanced gastric cancer. Methods Thirty-eight etderly patients of gastric cancer diagnosed in People' s Hospital of Heng County were randomly divided into two groups. Treatment group of 20 patients were received Paclitaxel combined with S-1 chemotherapy (the chemotherapy included Paclitaxel 60 mg/m2 intravenously on days 1, 8, 15 and S-1 capsule 80 mg/m2 twice daily for 14 days, every 28 days repeated). The control group of 18 patients were received FP chemotherapy (the chemotherapy included Cisplatin 15 mg/m2 intravenously every day from the first day to fifth day, Fluorouraeil 750 mg/m2 intravenously every day from first day to fifth day, every 28 days repeated). Efficacy and toxici- ty were evaluated at least 2 cycles of treatment between two groups. Results The efficiency of the treatment group and control group were 40.0% , 22.2% , the disease control rates were 75.0% , 50.0% , the 1-year survival rates were 55.0% , 38.9% (P 〉0.05). Quality of life of treatment group was better than that of the control group (P 〈 0. 05). The gastrointestinal reaction and Ⅲ-Ⅳ bone marrow suppression of the treatment group were significantly lower than the control group (P 〈 0.05). Conclusion The chemotherapy of S-1 combined with weekly Paclitaxel is efficient. Eld- erly patients could tolerate this treatment. It is valuable chemotherapy for elderly patients with advanced gastric cancer.
出处
《胃肠病学和肝病学杂志》
CAS
2014年第12期1420-1422,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
替吉奥
紫杉醇
胃癌
化疗
老年人
S-I
Paclitaxel
Gastric cancer
Chemotherapy
Elderly