非酒精性脂肪性肝病与幽门螺杆菌感染的相关性

Association between nonalcoholic fatty liver disease and Helicobacter pylori

目的 探讨非酒精性脂肪性肝病（NAFLD）与幽门螺杆菌（H.pylori）感染之间的关系.方法 采用横断面研究方法,分析2011年于北京医院体检中心进行健康体检者中体检数据完整、进行13C-尿素呼气试验检测H.pylori及腹部超声检查的受试者14 373人（年龄≥18岁）的体检数据.应用非条件Logistic回归分析H.pylori感染状态与NAFLD的关系.结果 NAFLD及H.pylori感染检出率均在50 ～ 59岁年龄段最高,分别达46.27％和32.38％.NAFLD及H.pylori感染检出率随年龄变化趋势相同.NAFLD患者中H.pylori阳性者较H.pylori阴性者体质量指数（BMI）高、甘油三酯（TG）高,而高密度脂蛋白胆固醇（HDL-C）低（P＜0.05）,肝功指标、血糖、尿酸无显著差异（P＞0.05）.H.pylori感染状态与NAFLD呈正相关（OR=1.265,95％ CI：1.116～ 1.403）.结论 H.pylori感染与NAFLD呈正相关,H.pylori感染可能是NAFLD发生的危险因素.

Objective To explore the relationship between the infection with H. pylori and NAFLD. Methods Medical check-up datas from the 14 373 physical examination participates （age≥ 18 years old） in 2011 who had con- ducted the 13 C urea breath test for detection of H. priori and abdominal ultrasound examination were analyzed. Cross-sec- tional analysis were carried out. Unconditional Logistic regression analysis was performed to analyze the relationship be- tween H. priori and NAFLD. Results The detection rates of NAFLD and H. priori infection in the 50 - 59 years old were highest, 46.27% and 32.38% , respectively. The detection rates of NAFLD and H. priori infection had the same change trend of age. In the NAFLD patients, BMI, TG of the infection with H. priori were higher than those noninfec- tion, while HDL-C was lower （P 〈0.05）. H. priori infection was closely related to NAFLD （OR = 1. 265, 95% CI： 1.116 - 1. 403 ）. Conclusion H. pylori infection is closely related to NAFLD in Chinese population. The infection with H. priori may be a risk factor in the development of NAFLD.