CTLA-4+49A/G基因多态性与乳腺癌易感性的Meta分析

A meta-analysis of association between CTLA-4 + 49A / G polymorphism and breast cancer susceptibility

目的探讨细胞毒性T淋巴细胞相关抗原4（CTLA-4）＋49A/G基因多态性与乳腺癌易感性的关系。方法计算机检索Pub Med、MEDLINE、Web of Science、EMBASE、中国知网及万方等数据库,检索时间截止于2014年6月。收集关于CTLA-4＋49A/G基因多态性与乳腺癌易感性关系的研究,由2名评价者按照纳入和排除标准独立选择文献、提取资料、评价质量。采用Rev Man 5.1软件进行Meta分析,计算比值比（OR）及其95%可信区间（CI）并行敏感性分析和发表偏倚评估。结果最终纳入5篇文献,包括3237例乳腺癌患者和3242例对照人群。纳入数据在AA vs.GG、AG vs.GG、AG/AA vs.GG和A vs.G基因型的比较中均无异质性。各模型Meta分析结果显示,CTLA-4＋49A/G基因多态性与乳腺癌易感性有统计学意义（AA vs.GG：OR=1.49,95%CI：1.10~2.00;AG vs.GG：OR=1.23,95%CI：1.10~1.37;AG/AA vs.GG：OR=1.27,95%CI：1.14~1.40;A vs.G：OR=1.19,95%CI：1.11~1.29）。结论 CTLA-4＋49A/G基因多态性与乳腺癌易感性有关,值得进一步研究。

Objective To explore the correlation between polymorphism of cytotoxic T lymphocyte antigen-4（ CTLA-4） ＋49A / G and susceptibility to breast cancer. Methods All eligible case-control studies published up to June 2014 were searched out from Pub Med,MEDLINE,Web of Science,EMBASE,CNKI and Wan Fang databases. Two reviewers independently identified the literature,extracted data and assessed the quality of included studies according to inclusion and exclusion criteria. Meta-analysis was performed using Rev Man5. 1 software to analyze. Results A total of 5 studies comprising 3237 patients and 3242 controls were finally included. The included studies showed good homogeneity in the four genetic models of AA vs. GG,AG vs. GG,AG / AA vs. GG,A vs. G.There was significant association between CTLA-4 ＋ 49 A / G polymorphism and breast cancer susceptibility（ AA vs. GG： OR = 1. 49,95% CI： 1. 10-2. 00; AG vs. GG： OR = 1. 23,95% CI： 1. 10-1. 37; AG / AAvs. GG： OR = 1. 27,95% CI： 1. 14-1. 40; A vs. G： OR =1. 19,95% CI： 1. 11-1. 29）. Conclusion There is significant association between polymorphism of CTLA-4 ＋ 49 A / G and susceptibility to breast cancer.