眼底血管造影中荧光素钠两种过敏试验方法比较

Comparisons between two different allergenic tests using Fluorescein Sodium Injection in fundus fluorescein angiography

目的 眼底血管造影时比较荧光素钠注射液皮内注射和静脉注射两种过敏试验方法的阳性率和安全性.方法 回顾性分析2011年8月到2013年8月在连云港市第一人民医院眼科拟进行眼底血管造影的患者612例（男403例,女209例）,年龄19～78岁（平均53.1岁）.其中采用皮内注射过敏试验者382例,静脉注射过敏试验者230例.比较皮内注射和静脉注射两种过敏试验方法的阳性率,分析过敏试验阴性患者行眼底血管造影检查的安全性.结果 采用皮内注射过敏试验者阳性率7.9％（30/382）,静脉注射过敏试验者阳性率1.7％ （4/230）,前者显著高于后者,差异有统计学意义（P＜o.05）.试验阴性者进行眼底血管造影,结果显示,皮内注射过敏试验阴性者过敏反应发生率0.28％（1/352）,静脉注射过敏试验阴性者过敏反应发生率0.44％ （1/226）,差异无统计学意义（P＞0.05）.结论 两种过敏试验方法的安全性无明显差别,但皮内注射过敏试验可能会导致更多的假阳性.

Objective To compare the positive rate and safety of Fluorescein Sodium Injection intradermal injections with intravenous injections in fundus fluorescein angiography （FFA）.Methods A total of 612 cases were arranged to receive FFA （male 403 cases,female 209 cases） from August 2011 to August 2013.The age ranged from 19 to 78 years old （mean age 53.1 years old）,382 cases received Fluorescein Sodium Injection intradermal injections and 230 cases received Fluorescein Sodium Injection intravenous injections.The data of positive rate of allergenic tests and the safety were retrospectively analyzed.Results Among 612 cases,30 receiving intradermal injections cases had positive allergenic tests （7.9％） and that was 4 in patients receiving intravenous injections （1.7％）,the positive rate in the former group was greatly higher than that in the later group （P ＜ 0.05）.All the negative allergenic tests patients receive FFA.One patient had an allergy to Fluorescein Sodium Injection in intradermal injections group （0.28％） and there was also one in intravenous injections group （0.44％,P ＞0.05）.Conclusions There are no significance between the both allergenic tests; however,the intradermal injections could lead to higher false positive.