摘要
目的:探讨5-氨基酮戊酸光动力疗法(ALA-PDT)治疗外阴硬化性苔藓(VLS)的可行性和有效性。方法:将60例经病理检查确诊为VLS的患者随机分为两组,每组30例。实验组采用浓度为20%的ALA-PDT治疗6次,治疗间隔时间为2~3周;对照组局部涂抹卤米松乳膏,第1月2次/天,第2~3月1次/天,第4~6月2次/周。治疗结束后随访6月比较临床疗效,并观察ALA-PDT治疗前后白斑范围及病理检查变化。结果:实验组总有效率达96.67%(29/30),对照组为73.33%(7/30),实验组总有效率明显高于对照组(2=6.41,P〈0.05)。实验组ALA-PDT治疗前后白斑范围对比差异有统计学意义(t=19.02,P〈0.01),治疗后病理检查结果显示表皮及真皮层组织结构均恢复正常。治疗过程中,除疼痛以外无其他不良反应。结论:20%ALA-PDT治疗VLS安全、有效,可作为治疗VLS的新方法。
Objective: To explore the efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in vulvar lichen selerosus (VLS). Methods:The total 60 patients with vulvar lichen sclerosus definitely diagnosed by pathological examination were randomly divided into 2 groups. 30 patients in experimental group were treated with ALA-PDT (20%). The total treatments are 6 times, the interval treatment time was 2 to 3 weeks. The other 30 patients in control group were treated with halometasone cream in any on-spot treatments: 2 times per day at first month, 1 time per day from the second month to the third month, 2 times per week from the fourth month to the sixth month. The total treatments are 6 times. The symptoms, signs and the structure of skin tissue were observed with or without ALA-PDT treatment. Results: After treated with 20% ALA-PDT, The ratio of total efficiently was 96.67% (29/30), which was higher than that in control group (73.33%) , X2 =6. 41, P 〈0. 05. The scope of the original spot in experiment group was statisti- cally significant decrease compared with the control group ( t = 19.02 ,P 〈 0.01 ). Pathological ex- amination showed that the structure of skin and dermis tissues recovered to normal with ALA-PDT treatment. There were seldom adverse reactions except for pain during the treatment. Conclusion: ALA-PDT, an effective and safety method, might be applied to treat with VLS.
出处
《皮肤性病诊疗学杂志》
2014年第6期450-454,共5页
Journal of Diagnosis and Therapy on Dermato-venereology