枸橼酸咖啡因与氨茶碱治疗早产儿原发性呼吸暂停疗效对比

The curative effect contrast between caffeine citrate and aminophylline in treatment of primary apnea of prematurity

目的对比枸橼酸咖啡因与氨茶碱治疗早产儿原发性呼吸暂停的疗效。方法原发性早产儿呼吸暂停患儿59例,随机分为咖啡因组32例和氨茶碱组27例。对比两组患儿治疗总有效率及呼吸暂停终止时间。结果咖啡因组总有效率明显高于氨茶碱组(87.5%vs 63.0%,x2=6.408,P=0.041),咖啡因组呼吸暂停终止时间明显短于氨茶碱组[(2.9±1.2)d vs(3.5±1.0)d,t=-2.063,P=0.044]。结论咖啡因治疗早产儿呼吸暂停疗效优于氨茶碱。

Objective To compare the effect of caffeine citrate and aminophylline in treatment of primary apnea of prematurity. Methods 59 cases of preterm infant with primary apnea were divided into two groups, the group treated by caffeine citrate（32 cases） and the group treated by aminophylline（27 cases）. To compare the efficiency and apnea termination time between two groups. Results Compared with the aminophylline group, the total effective rate of the caffeine group was higher（87.5%vs 63%, χ2=6.408, P=0.041）, and the apnea termination time was shorter[（2.9±1.2）d vs （3.5±1.0）d, t=-2.063, P=0.044]. Conclusion Caffeine citrate is more effective than aminophylline in treatment of primary apnea of prematurity.