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CCN2在软骨内成骨过程中作用的研究进展

Advances on the Role of CCN2 in the Process of Endochondral Ossification
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摘要 在软骨内成骨过程中．由骨髓间充质干细胞分化而来的软骨细胞首先形成生长板软骨．随着软骨中血管的产生．软骨逐渐被骨组织所替代。躯干骨和四肢骨以及骨折后的骨痂主要是通过软骨内成骨完成生长发育和修复．此过程受到许多生长因子以及激素的影响。
作者 盛夏涵 蔡协艺
机构地区 上海交通大学医学院附属第九人民医院口腔颌面外科
出处 《口腔颌面外科杂志》 CAS 2014年第6期467-471,共5页 Journal of Oral and Maxillofacial Surgery
基金 国家自然科学基金(81200766) 上海市科学技术委员会资助项目(13140902702)
关键词 CCN2 软骨内成骨 软骨细胞 成骨细胞 破骨细胞 CCN2 endochondral ossification chondrocytes osteoblasts osteoclasts
分类号 R782 [医药卫生—口腔医学]
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  • 1Takigawa M. CTGF/Hcs24 as a multifunctional growth fac- tor for fibroblasts, chondrocytes and vascular endothelial cells [J]. Drug News Perspect, 2003, 16(1): 11-21.
  • 2Brigstock DR, Goldschmeding R, Katsube KI, et al. Pro- posal for a unified CCN nomenclature[J]. Mol Pathol, 2003, 56(2): 127-128.
  • 3Yamaai T, Nakanishi T, Asano M, et al. Gene expression of connective tissue growth factor (CTGF/CCN2) in calcify- ing tissues of normal and cbfal-null mutant mice in late stage of embryonic development [J]. J Bone Miner Metab, 2005, 23(4): 280-288.
  • 4Igarashi A, Nashiro K, Kikuchi K, et al. Connective tissue growth factor gene expression in tissue sections from local- ized scleroderma, keloid, and other fibrotic skin disorders [J]. J Invest Dermatol, 1996, 106(4): 729-733.
  • 5Nishida T, Kubota S, Nakanishi T, et al. CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondroeytes [J]. J Cell Physiol, 2002, 192(1): 55-63.
  • 6Maeda A, Nishida T, Aoyama E, et al. CCN family 2/con- nective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes [J]. J Biochem, 2009, 145(2): 207-216.
  • 7Nishida T, Kubota S, Aoyama E, et al. Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 pro- ductions by chondrocytes[J]. Endocrinology, 2011, 152(11): 4232-4241.
  • 8Aoyama E, Kubota S, Takigawa M. CCN2/CTGF binds to fibroblast growth factor receptor 2 and modulates its sig- naling [J]. FEBS Letters, 2012, 586(24): 4270-4275.
  • 9Inoki I, Shiomi T, Hashimoto G, et al. Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis [J]. FASEB J, 2002, 16(2): 219-221.
  • 10Gao R, Brigstock DR. Low density lipoprotein receptor-re- lated protein (LRP) is a heparin-dependent adhesion recep- tor for connective tissue growth factor (CTGF) in rat acti- vated hepatic stellate cells [J]. Hepatol Res, 2003, 27(3): 214-220.
口腔颌面外科杂志
2014年 第6期

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