CXCR2在胰腺导管癌组织中的表达与患者预后关系

Prognostic significance of CXCR2 expression in pancreatic ductal carcinoma

目的 探讨CXC趋化因子受体2（CXCR2）在胰腺导管癌（PDAC）组织中的表达及其与临床病理及预后的相关性.方法 收集2006年1月至2008年1月南通大学附属医院和南京市鼓楼医院进行Whipple根治手术的PDAC病例161例标本及其相关的临床资料,将癌组织标本制成组织芯片,用鼠抗人CXCR2单克隆抗体,经免疫组织化学方法检测PDAC组织芯片中CXCR2蛋白表达情况,结合临床病理参数和随访资料进行统计学分析.结果 PDAC组织中CXCR2蛋白高表达54.04％ （87/161）,胰腺正常组织高表达率为30.77％ （24/78）,两者差异有统计学意义（x2=11.437,P=0.00l）.CXCR2在PDAC中的高表达与出现肿瘤侵犯血管（X2=6.489,P=0.011）及TNM分期晚（X2 =6.205,P =0.013）有关,差异有统计学意义.Log-rank单因素生存分析和Kaplan-Meier生存曲线确定CXCR2高表达和患者预后差异有统计学意义（P＜0.05）,生存函数Cox回归多因素生存分析显示,CXCR2高表达（HR：5.514,P=0.016）是胰腺癌患者预后差的独立危险因素.结论 PDAC肿瘤组织中CXCR2高表达提示患者预后差.

Objective To explore the relationship between the expression of CXC chemokine receptor 2 （CXCR2） and the clinicopathologic features with prognosis in pancreatic ductal carcinoma （PDAC） tissues.Methods The CXCR2 expression in 161 PDAC tissues were detected with immunohistochemistry using anti-human CXCR2 antibody and tissues microarray.Results The expression of CXCR2 in PDAC tumor tissues was higher than that in normal pancreatic tissues （X2 =11.437,P =0.001）.The comparison of clinicopathologic characteristics and immunohistochemistry by x2 test analysis showed that a high expression of CXCR2 in PDAC was correlated with vascular invasion （x2 =6.489,P =0.011） and late TNM stage （x2 =6.205,P =0.013）.Kaplan-Meier survival and Cox regression analyses showed that a high expression of CXCR2 （HR：5.514,P =0.016） was an independent prognostic factor.Conclusion A high expression of CXCR2 denotes a poor prognosis in PDAC.