期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肌球蛋白轻链激酶在炎症性肠病中的作用 被引量：4

Role of myosin light chain kinase in inflammatory bowel disease
下载PDF
导出
摘要 肌球蛋白轻链激酶(myosin light chain kinase,M L C K)依赖的肌球蛋白轻链(m y o s i n l i g h t c h a i n,M L C)磷酸化在炎症性肠病(i n f l a mmatory bowel disease,IBD)的发病机制中起重要作用,MLC的磷酸化引起细胞骨架收缩是肠上皮屏障破坏的必要因素,MLCK的表达增加能介导上皮屏障功能障碍.目前主要侧重于MLCK在肠上皮屏障损害中的作用机制研究,本文对MLCK在IBD中的作用作一综述. Myosin light chain kinase （MLCK） dependent myosin light chain （MLC） phosphorylation plays an important role in the pathogenesis of inflammatory bowel disease （IBD）. Cytoskeletal contraction induced by the phosphorylation of MLC is essential for the destruction of the intestinal epithelial barrier, and increased expression of MLCK can mediate epithelial barrier dysfunction. Currently studies focused mainly on the mechanism of MLCK in the intestinal epithelial barrier. This review discusses the role of MLCK in IBD.
作者 易在凤 范恒 杨佳
机构地区 华中科技大学同济医学院附属协和医院中西医结合科
出处 《世界华人消化杂志》 CAS 北大核心 2014年第35期5467-5472,共6页 World Chinese Journal of Digestology
关键词 炎症性肠病 肌球蛋白轻链激酶 肠上皮屏障 细胞因子 Inflammatory bowel disease Myosin light chain kinase Intestinal epithelial barrier Cytokines
分类号 R574 [医药卫生—消化系统]
  • 相关文献

参考文献50

  • 1Gardiner KR, Anderson NH, Rowlands BJ, Barbul A. Colitis and colonic mucosal barrier dysfunction. Gut 1995; 37:530-535 [PMID: 7489941 DOI: 10.1136/ gut.37.4.530].
  • 2高金生,杨书良.肠黏膜屏障损伤的原因与机制研究进展[J].世界华人消化杂志,2009,17(15):1540-1544. 被引量：51
  • 3Pio R, Martinez A, Unsworth EJ, Kowalak JA, Ben- goechea JA, Zipfel PF, Elsasser TH, Cuttitta F. Com- plement factor H is a serum-binding protein for ad- renomedullin, and the resulting complex modulates the bioactivities of both partners. J Biol Chem 2001; 276:12292-12300 [PMID: 11116141 DOI: 10.1074/jbc. M007822200].
  • 4Belvitch P, Adyshev D, Elangovan VR, Brown ME, Naureckas C, Rizzo AN, Siegler JH, Garcia JG, Dudek SM. Proline-rich region of non-muscle myosin light chain kinase modulates kinase activity and endothelial cytoskeletal dynamics. Microvasc Res 2014; 95:94-102 [PMID: 25072537 DOI: 10.1016/ j.mvr.2014.07.007].
  • 5Hong F, Haldeman BD, Jackson D, Carter M, Baker JE, Cremo CR. Biochemistry of smooth muscle my- osin light chain kinase. Arch Biochem Biophys 2011; 510:135-146 [PMID: 21565153 DOI: 10.1016/j.abb. 2011].
  • 6Kanoh S, Ito M, Niwa E, Kawano Y, Hartshorne DJ. Actin-binding peptide from smooth muscle myosin light chain kinase. Biochemistry 1993; 32: 8902-8907 [PMID: 8364036 DOI: 10.1021/bi000 85a023].
  • 7Smith L, Su X, Lin P, Zhi G, Stull JT. Identification of a novel actin binding motif in smooth muscle myosin light chain kinase. J Biol Chem 1999; 274: 29433-29438 [PMID: 10506206 DOI: 10.1074/jbc.274. 41.29433].
  • 8Gallagher PJ, Stull JT. Localization of an actin bind-ing domain in smooth muscle myosin light chain kinase. Mol Cell Biochem 1997; 173:51-57 [PMID: 9278254 DOI: 10.1023/A:1006876318155].
  • 9Ye LH, Hayakawa K, Kishi H, Imamura M, Na- kamura A, Okagaki T, Takagi T, Iwata A, Tanaka T, Kohama K. The structure and function of the actin-binding domain of myosin light chain ki- nase of smooth muscle. ] Biol Chem 1997; 272: 32182-32189 [PMID: 9405419 DOI: 10.1074/jbc. 272.51.32182].
  • 10Sellers JR, Pato MD. The binding of smooth muscle myosin light chain kinase and phosphatases to actin and myosin. J Biol Chem 1984; 259:7740-7746 [PMID: 6330077].

二级参考文献32

共引文献66

同被引文献44

  • 1曹倩,胡伟玲,高敏,周刚,姒健敏.379例炎症性肠病临床特征分析[J].中华消化杂志,2005,25(4):222-225. 被引量：29
  • 2Mark F van Delft,David CS Huang.How the Bcl-2 family of proteins interact to regulate apoptosis[J].Cell Research,2006,16(2):203-213. 被引量：39
  • 3王勇生,桂淑玉,李永怀,周青,胡向阳,吴强,汪渊.哮喘模型大鼠支气管平滑肌肌球蛋白轻链激酶的表达[J].安徽医科大学学报,2006,41(1):1-3. 被引量：1
  • 4李锦师,白建文,林闽加,张斗霞.肌球蛋白轻链激酶在急性肺损伤模型的表达及意义[J].上海交通大学学报（医学版）,2007,27(12):1424-1427. 被引量：3
  • 5Ewald N, Hardt PD, Kloer HU. Severe hypertriglyceridemia and pancreatitis: presentation and management. Curr Opin Lipidol 2009; 20:497-504 [PMID: 19770656 DOI: 10.1097/ MOU0b013e3283319ald].
  • 6Shen Q, Rigor RR, Pivetti CD, Wu MH, Yuan SY. Myosin light chain kinase in microvascularendothelial barrier function. Cardiovasc Res 2010; 87:272-280 [PMID: 20479130 DOI: 10.1093/cvr/ cvq144].
  • 7Nishida M, Yoshida M, Nishiumi S, Furuse M, Azuma T. Claudin-2 regulates colorectal inflammation via myosin light chain kinase- dependent signaling. Dig Dis Sci 2013; 58: 1546-1559 [PMID: 23306855 DOI: 10.1007/ s10620-012-2535-3].
  • 8Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev hnmunol 2009; 9: 799-809 [PMID: 19855405 DOI: 10.1038/nri2653].
  • 9Gao L, Grant A, Halder I, Brower R, Sevransky J, Maloney JP, Moss M, Shanholtz C, Yates CR, Meduri GU, Shriver MD, Ingersoll R, Scott AF, Beaty TH, Moitra J, Ma SF, Ye SQ, Barnes KC, Garcia JG. Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury. Am J Respir Cell Mol Biol 2006; 34:487-495 [PMID: 16399953 DOI: 10.1165/rcmb.2005- 0404OC].
  • 10Mirzapoiazova T, Moitra J, Moreno-Vinasco L, Sarnmani S, Turner JR, Chiang ET, Evenoski C, Wang T, Singleton PA, Huang Y, Lussier YA, Watterson DM, Dudek SM, Garcia JG. Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury. Am J Respir Cell Mol Biol 2011; 44: 40-52 [PMID: 20139351 DOI: 10.1165/rcmb.2009- 0197OC].

引证文献4

二级引证文献9

世界华人消化杂志
2014年 第35期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部