p53和β-catenin在胆囊癌组织中的表达及意义

Clinical significance of expression of p53 and β-catenin in gallbladder carcinoma

目的:探讨p53和β-catenin在胆囊癌组织中的表达及其意义.方法:应用免疫组织化学检测p53和β-catenin在58例胆囊癌、10例胆囊腺瘤性息肉及20例慢性胆囊炎中的表达,并对结果进行统计学分析.结果:(1)胆囊癌组p53和β-catenin的表达阳性率(62.07%,68.97%)明显高于胆囊腺瘤性息肉组(33.33%,40.00%)及慢性胆囊炎组(10.00%,5.00%)(P<0.05);(2)p53和β-c atenin在胆囊癌中的表达无明显相关性(P>0.05);(3)胆囊癌高分化、NevinⅠ-Ⅲ期、未侵犯周围组织器官病例阳性率明显低于中低分化、NevinⅣ-Ⅴ期、有侵犯周围组织器官病例(P<0.05).结论:p53和β-catenin在胆囊癌的发生发展以及临床生物学特征有密切关系.

AIM： To examine the expression of p53 and β-catenin in gallbladder carcinoma and to analyze their significance. METHODS： The expression of p53 and β-catenin in 58 gallbladder carcinoma specimens, 10 adenomatous polyp specimens and 20 chronic cholecystitis specimens was detected by immunohistochemistry. RESULTS： The positive expression rates of p53 and β-catenin in gallbladder carcinoma （62.07%, 68.97%） were significantly higher than those in adenomatous polyps （33.33%, 40.00%） and chronic cholecystitis （10.00%, 5.00%） （P 〈 0.05）. There was no significant correlation between the expression of p53 and that of β-catenin in gallbladder carcinoma （P 〉 0.05）. The positive expression rates of p53 and β-catenin were lower in well differentiated than in moderately and lowly differentiated gallbladder carcinoma tissues, but lower in early stage （Nevin Ⅰ-Ⅲ） than in advanced stage （Nevin Ⅳ-Ⅴ） and in cases without lymph node metastasis or invasion of the surrounding tissues than in those with （P 〈 0.05）. CONCLUSION： The overexpression of p53 and β-catenin may be closely related to the initiation and biological behavior of gallbladder carcinoma.