自然杀伤细胞功能与维生素信号调节在免疫性肝病中的研究进展

Role of natural killer cells and vitamin signaling in autoimmune liver disease

自然杀伤细胞(natural killer cell,NK细胞)在肝脏中占有很大比例,通过分泌细胞因子和细胞间接触调节天然免疫和获得性免疫反应.NK细胞表达趋化因子受体迁移到炎症部位作用,与免疫性肝病发病相关.维生素相关代谢产物信号对NK细胞分化的调节是近年来受关注的热点,通过与细胞核受体相互作用实现功能调控,是自身免疫疾病治疗的新靶点.

Natural killer （NK） cells are a major group of human hepatic lymphocytes. Their precursors undergo a maturation process that leads to the acquisition of their effecter functions to regulate the innate and acquired immune responses. With the changes in the expression of chemotactic receptors and adhesion molecules, NK cells migrate to the target organ, leading to the immune-related liver diseases. The discovery of the vitamin signaling and vitamin receptor expression in NK cell lineage, particularly the interaction with nuclear receptors, suggests a novel role for vitamin signaling in modulating immunological function and in the development or prevention of autoimmune diseases.