中药方联合TCF方案化疗改善中晚期胃癌患者的疗效评价

Impact of traditional Chinese medicine combined with TCF regimen chemotherapy on quality of life in patients with advanced gastric cancer

目的:分析健脾通络方联合紫杉醇+亚叶酸钙+5-氟尿嘧啶(taxol+calcium folinate+5-fluorouracil,TCF)方案化疗改善中晚期胃癌患者生存质量临床效果.方法:收集2013-02/2014-02武汉市第三医院光谷关山院区收治的98例中晚期胃癌患者临床资料,按照不同的治疗方法,将患者分为对照组与研究组,每组均为49例.对照组患者单纯采取TCF方案化疗,研究组患者实施健脾通络方联合TCF方案化疗,最后分析两组患者的临床治疗效果.结果:研究组患者治疗总有效率显著高于对照组(71.43%vs 40.82%),差异具有统计学意义(P<0.05);研究组患者治疗后躯体功能、角色功能、认知功能、情绪功能和社会功能评分均显著升高,与治疗前比较(88.56分±11.24分vs 78.33分±13.24分、70.89分±12.03分vs 53.78分±14.67分、74.56分±11.24分vs 59.33分±13.24分、71.89分±12.03分vs 58.78分±14.67分、70.78分±14.86分v s 62.74分±15.46分),差异具有统计学意义(P<0.05);对照组患者治疗后角色功能、情绪功能和社会功能评分均显著升高,与治疗前比较(61.88分±12.02分vs 53.75分±13.80分、65.88分±14.00分vs 58.75分±13.80分、69.94分±14.89分v s 61.73分±13.85分),差异具有统计学意义(P<0.05);研究组患者治疗后躯体功能、角色功能、认知功能和情绪功能评分均显著高于对照组(88.56分±11.24分vs 80.53分±13.55分、70.89分±12.03分vs 61.88分±12.02分、74.56分±11.24分vs 62.53分±13.55分、71.89分±12.03分v s 65.88分±14.00分),差异具有统计学意义(P<0.05).结论:健脾通络方联合TCF方案化疗中晚期胃癌患者,可确保较高的治疗有效率,提高患者生存质量,值得临床推广.

AIM： To evaluate the impact of Jianpi Tongluo formula combined with taxol ＋ calcium folinate ＋ 5-fluorouracil （TCF） regimen chemotherapy on quality of life （QOL） in patients with advanced gastric cancer. METHODS： Ninety-eight patients with advanced gastric cancer were divided into either a control group （49 cases） or a research group （49 cases）. The control group was treated with TCF alone, and the research group was treated with Jianpi Tongluo formula combined with TCF. Clinical effects were compared for the two groups. RESULTS： The total effective rate for the research group was higher than that for the control group （81.63% vs 61.22%, P 〈 0.05）. The scores of physical functioning, role function, cognitive function, emotional functioning, and social function for the research group post treatment were significantly higher than those prior treatment （88.56 ± 11.24 vs 78.33 ± 13.24, 70.89 ± 12.03 vs 53.78 ± 14.67, 74.56 ± 11.24 vs 59.33 ± 13.24, 71.89 ± 12.03 vs 58.78 ± 14.67, 70.78 ± 14.86 vs 62.74 ± 15.46, P 〈 0.05 for all）. The scores of role function, emotional functioning, and social function for the control group post treatment were significantly higher than those prior treatment （61.88 ± 12.02 vs 53.75 ± 13.80, 65.88 ± 14.00 vs 58.75 ± 13.80, 69.94 ± 14.89 vs 61.73 ± 13.85, P 〈 0.05 for all）. The scores of physical functioning, role function, cognitive function, and emotional functioning for the research group post treatment were significantly higher than those for the control group （88.56 ± 11.24 vs 80.53 ± 13.55, 70.89 ± 12.03 vs 61.88 ± 12.02, 74.56 ± 11.24 vs 62.53 ± 13.55, 71.89 ± 12.03 vs 65.88 ± 14.00, P 〈 0.05 for all）. CONCLUSION： Jianpi Tongluo formula combined with TCF regimen chemotherapy has a higher effective rate in patients with advanced gastric cancer than chemotherapy alone, and it can increase the QOL.