4,6-二甲基-2-甲磺酰基嘧啶的合成

Synthesis of 4,6-Dimethyl-2-methanesulfonylpyrimidine

以硫脲为原料,经碳酸二甲酯甲基化,乙酰丙酮环合,再用过氧化氢氧化得到4,6-二甲基-2-甲磺酰基嘧啶,3步反应的总收率为71.0%。目标化合物结构经GC-MS、1H NMR确证。

4,6-Dimethyl-2-methanesulfonylpyrimidine i biologically active compounds. The target compound was p via methylation with dimethyl carbonate, condensation wi s an important intermediate for the synthesis of many repared in overall yield of 71.0% starting from thiourea th acetylacetone, and oxidation by hydrogen peroxide. The structure of target compound was characterized by 1H NMR and GC-MS spectra.