奥拉西坦治疗卒中后认知功能障碍的有效性及安全性分析

Analysis of the effectiveness and safety of oxiracetam in treatment of poststroke cognitive impairment

目的探讨奥拉西坦对脑卒中后认知功能障碍患者的临床疗效及安全性。方法选取我院收诊的脑卒中后认知功能障碍患者共70例,并以入院先后顺序将其分成2组,将30例实施常规治疗者纳入对照组,将40例在此条件下施加奥拉西坦治疗者纳入观察组,分析并评估两组病例的临床治疗结局。结果观察组治疗后7、14d和30d的MMSE评分和Barthel指数评分均要较其治疗前、对照组更理想,比较差异明显(P<0.05);在安全性方面,两组治疗期间均未见严重不适出现。结论为卒中后认知功能障碍患者提供奥拉西坦治疗有确切效果,且安全性可靠,适合在今后的临床上普及应用。

Objective To investigate the clinical efficacy and safety of Oxiracetam on patients with cognitive impairment after stroke.Methods Stroke in our hospital diagnosis of the patients with cognitive impairment after a total of 70 cases,and to the order of admission will be divided into 2 groups,30 cases received routine treatment were included in a control group,40 cases in these conditions applied oxiracetam were included in the observation group,the analysis and assessment of clinical outcomes of two groups cases.Results The observation group after treatment,7d,14 d and 30 d MMSE score and Barthel index scores than the control group before treatment,the more ideal,significant differences（P〈0.05）; in the aspect of safety,during the two groups were no serious discomfort appeared.Conclusion In order to provide patients with cognitive impairment after stroke oxiracetam treatment is effective,and safe,suitable for popularization and application in clinic.