乳腺癌根治术后放射治疗胸壁及腋窝的临床意义

Clinical significance of radical operation of breast cancer after radiotherapy to chest wall and axilla

目的研究乳腺癌根治术后放射治疗胸壁以及腋窝的临床价值。方法选取2010年1月—2011年4月入我院进行乳腺癌根治术后放射治疗患者118例,将其按照随机数字表分为甲组与乙组。甲乙两组均采用适行或传统放射治疗技术,甲组58例患者照射胸壁,乙组60例患者照射胸壁加锁腋野。两组患者照射剂量46-56GY,治疗时间为5-6周。在完成放射治疗后对比两组患者的生存率与复发率。结果乙组与甲组患者在接受放射治疗后近期总体缓解率不存在显著差异,无统计学意义,P〉0.05;甲组患者的生存率与复发率和乙组相比无显著差异,无统计学意义,P〉0.05。但乙组患者进行腋窝照射存在一定的副作用,降低了患者的生存质量。结论研究未得出乳腺癌根治术后采用适行或传统放射治疗照射胸壁或胸壁加锁腋野有利于提高局部控制率,降低复发率,但是照射胸壁加锁腋野存在一定的副作用,在实施时需要加以考虑。胸壁放射治疗的价值及术后放射治疗靶区的个体化确定需要更多的随机研究来证实。

Objective Clinical value of radical operation of breast cancer after radiotherapy to chest wall and axilla.Methods Select the January 2010 April 2011 into my hospital for radiotherapy after radical mastectomy patients 118 cases,which according to the random number table is divided into Group A and Group B.B groups were appropriate line or conventional radiotherapy techniques,Group A chest wall irradiation of 58 patients,60 patients in Group B lock axillary chest wall irradiation field.Dose groups were 46-56GY,treatment time is 5-6 weeks.After the completion of radiation therapy comparing survival and relapse rates of the two groups of patients.Results In group B and group A patients undergoing radiotherapy after the recent overall response rate of no difference,no statistically significant,P〉0.05; survival rate and recurrence rate of group A and group B were not significantly different,not statistically significant,P〉0.05.But in group B underwent some side effects of axillary irradiation,lower the quality of life of the patients.Conclusion Study did not come after radical mastectomy of breast cancer with conformal or conventional radiotherapy for chest wall or chest wall lock axillary wild is conducive to improve the local control rate,reduce the recurrence rate,but the chest wall irradiation lock axillary wild some side effects to be considered when implementing,need.To determine the value and postoperative chest wall radiotherapy radiotherapy target individual random more research is needed to confirm.