补益肝肾方、脑心通与银杏叶注射液联合西药治疗脑梗死恢复期神经功能缺损随机平行对照研究

Fang Combined Liver and Kidney Tonic Medicine Treatment of Cerebral Infarction Neurological Deficit Recovery Randomized Parallel Group Study

[目的]观察补益肝肾方、脑心通与银杏叶注射液联合西药治疗脑梗死恢复期神经功能缺损疗效。[方法]使用随机平行对照方法,将60例住院患者按抽签法简单随机分为两组。戒烟酒,适劳逸,畅情志,安静休息,禁食生冷、辛辣、油腻或海鲜等发物,适当功能康复训炼。对照组30例阿斯匹林肠溶片,100mg/次,1次/d;脑心通,0.8g/次,3次/d;银杏叶注射液10~15m L＋250m L5%葡萄糖（合并糖尿病用250m L0.9%氯化钠）,1次/d,静滴。治疗组30例补益肝肾方（熟地20g,山茱萸9g,枸杞子、白芍各15g,巴戟天、肉苁蓉各12g,麦冬、石斛各10g,五味子9g,山药15g,茯苓6g,当归15g,丹参12g,川芎6g,地龙12g,川牛膝15g,甘草6g;视目昏花加决明子、菊花各15g;心悸失眠加酸枣仁、远志各15g,夜交藤30g;头痛高血压加全蝎、僵蚕各6g,石决明30g;肢体麻木加葛根、鸡血藤各30g,伸筋草18g;舌苔自腻肢体困乏加竹茹9g,全瓜萎18g,半夏12g;肢体无力加桑寄生、杜仲各18g）,1剂/d,水煎200m L,早晚温服;阿斯匹林、脑心通联合银杏叶注射液治疗同对照组。连续治疗10d为1疗程。观测临床症状、弥散加权成像、灌注加权成像、磁共振血管成像、CT血管成像、功能缺损评分、不良反应。连续治疗3疗程,判定疗效。[结果]治疗组痊愈12例,显效8例,有效8例,无效2例,总有效率93.33%。对照组痊愈4例,显效7例,有效13例,无效6例,总有效率80.00%。治疗组疗效优于对照组（P〈0.05）。[结论]补益肝肾方、脑心通与银杏叶注射液联合西药治疗脑梗死恢复期神经功能缺损效果显著,值得推广。

[Objective]To observe the parties combined liver and kidney tonic medicine treatment of cerebral infarction recovery of neurological deficit effect. [Methods]Random parallel control method, 60 cases of hospitalized patients were randomly divided into two groups balloting method is simple. On blood pressure, blood sugar interventions, quit alcohol, fitness work and rest, Emotions, quiet rest, fasting cold, spicy, greasy or seafood such as fat objects, proper rehabilitation Workout. A control group of 30 patients aspirin entericcoated tablets, 100mg/times, 1 times/d. Naoxintong, 0.8g / time, 3 times / d. 10 ~ 15 m L of Ginkgo biloba L＋250 m L5% glucose（diabetes with 250 m L0.9% sodium chloride）, 1 times / d, intravenous infusion. Treatment group of 30 patients and kidney tonic side（Shudi 20 g,Shanzhuyu9g, Gouqizi,Baishao 15 g, Bajitian,Roucongrong 12 g, Maidong,Shihu10 g, Wuweizi9 g, Shanyao15 g,Fuling6g, Danggui15 g, Danshen 12 g, Chuanqiong 6g, Dilong12 g, Chuanniuxi15 g, Gancao 6g; depending on the mesh dim plus Juemingzi,Juhua 15g; palpitations, insomnia plus Suanzaoren,Yuanzhi 15 g,Yejiaoteng30g; headache, hypertension plus Quanxie,Jiangcan each 6g, Shijueming30g; numbness Gegen,Jixueteng30 g, Shenjincao18g; tongue from tired and weary limbs plus Zhuru 9g, Quangualou18 g, Banxia12g; limb weakness Sangjisheng,Duzhong18g）; 1/ d, decoction 200 ml, morning and evening, warm clothes. Western medicine with the control group. 10 d is a continuous course of treatment. Observing clinical symptoms of adverse reactions. Continuous treatment for 3 courses, to determine efficacy. [Results] The cure 12 cases, 8 cases, 8 cases, 2 cases, the total efficiency of 93.33%. The control group healed in 4 cases, 7 cases were markedly effective in 13 cases, six cases, the total efficiency 80.00%. Treatment group than the control group（P〈0.05）. [Conclusion] parties combined liver and kidney tonic medicine treatment ofcerebral infarction recovery of neurological deficit effect is remarkable, worthy of promotion.