儿童过敏性紫癜免疫因子研究概况

The Research Progress of Immune Factors Children Henoch-Schonlein Purpura

过敏性紫癜属"葡萄疫"、"斑毒"等范畴,为六淫之邪侵袭,伤及血络,血不循常道,或摄食异物,素体不受,或药物过敏,致热毒入侵,热伤血络,血溢脉外,渗于肌肤而发斑。从IL-6发病机制、临床观察(西医、中医),VCAM-1发病机制、临床观察(西医、中医)等方面,介绍儿童过敏性紫癜免疫因子研究概况。过敏性紫癜发病机制尚不完全明确,但发病机制与机体免疫功能异常有关,多种免疫因子参与发病,IL-6及VCAM-1参与过敏性紫癜发病过程。过敏性紫癜治疗、预后及肾损害评估仍需大量临床研究,重视中医四诊结合辨证,采取中西医结合治疗手段,提高治愈率及改善预后。

HSP is a ＂grape disease＂, such as ＂spot＂ category. The six evils of the mainly for the evil, invasion and blood, the blood doesn’t abide often, or ingestion of foreign bodies, ferrite isn’t affected by, or drug allergy, toxic heat invasion, heat injury of blood vessels, blood discharge pulse, permeability in skin and hair spot. From IL- 6 pathogenesis, clinical observation（western medicine, Chinese medicine）, pathogenesis, clinical observation VCAM- 1（western medicine, Chinese medicine）, etc.To introduce HSP immune factors. HSP pathogenesis is not fully clear, but the mechanism is associated with the abnormal immune function, a variety of immune factors participate in the onset, IL- 6 and VCAM 1 disease process involved in HSP. HSP treatment, prognosis, and renal damage evaluation still needs a large number of clinical research, attaches great importance to the combination of four diagnosis in traditional Chinese medicine syndrome differentiation, to combine traditional Chinese and western medicine treatment,to improve the cure rate and prognosis.