妊娠期糖尿病患者骨钙素和β-胶原特殊序列水平分析

Detection of Serum Osteocalcin and β-CrossLaps Levels in Gestational Diabetes Mellitus

目的分析妊娠期糖尿病患者骨钙素及β-胶原特殊序列水平的特点,为明确骨代谢与糖代谢之间相互作用的机制提供依据。方法病例对照研究。30例GDM患者纳入本研究(GDM组),收集血清检测血糖、N端骨钙素中分子片段和β-胶原特殊序列,另收集30例糖耐量正常的孕妇作为对照(NGT组)。结果 GDM组孕妇的骨钙素为14.95±4.16μg/L,高于NGT组的12.65±3.09μg/L(P=0.017);β-胶原特殊序列为0.339±-0.124μg/L,高于NGT组的0.272±0.086μg/L(P=0.018)。结论妊娠期糖尿病患者骨吸收代谢水平和骨转换率均高于一般孕妇,明确骨-糖代谢的相互作用尚需进一步深入研究。

Objective To investigate the characteristic of serum osteocalcin and β-Cross Laps level in gestational diabetes mellitus. Methods 30 gestational diabetic patients（GDM group） and 30 pregnant women with normal glucose tolerance（ NGT group） were included in this study. 3he levels of serum glucose,N-MID osteocalcin and β- cmsslaps were detected and compared. Results Serum N-MID osteocalcin and β-crosslaps levels in GDM group were significantly higher than those in NGT group（P =0.017 and P =0. 018, respectively）. Conclusion Bone resorption and turnover level in gestational diabetic patients are higher than pregnmat women with normal glucose tolerance.