维生素D水平与平均血小板体积变化的相关性研究

The Correlation Between the Vitamin D Level and Mean Platelet Volume

目的 探讨维生素D水平与平均血小板体积（MPV）的相关性。方法 选取患者420例测定维生素D水平及MPV。根据测得维生素D水平将病例分为组1：维生素D〈10ng/mL;组2：维生素D为10~20ng/mL;组3：维生素D〉20ng/mL。比较各组检测结果,分析维生素D水平与MPV变化的相关性。结果 三组维生素D水平分别为8.9±2.1ng/mL,14.3±1.7 ng/mL,24.2±5.9 ng/mL,差异有统计学意义（P〈0.001）。三组患者MPV分别为8.3±1.7fL,8.0±1.4fL,7.3±1.5fL。组3与组1、组2 MPV差异有统计学意义（P〈0.001;P=0.006）。维生素D水平与MPV存在负相关（r2=0.337,P〈0.001）。结论 维生素D水平与MPV密切相关,维生素D的缺乏可能导致MPV升高。

Objective To investigate the correlation between the vitamin D level and mean platelet volume （MPV）. Methods 420 patients were collected. According to the vitamin D level, the patients were allocated to Group 1 （ vitamin D 〈 10ng/mL）, Group 2 （ vitamin D, 10-20ng/mL）, Group 3 （ vitamin D 〉 20ng/mL）, respectively. The vitamin D level and mean platelet volume in all patients were detected. Results The vitamin D level in Group 1 （7.7 ± 1.9ng/mL） was lower than that in Group 2 （ 14.3 ±1.7 ng/mL, P 〈0.001 ） and Group 3 （24.2 ±5.9 ng/mL, P 〈0.001 ）. The MPV in Group 3 （7.3 ± 1.5 fL） was lower than that in Group 1 （8.3 ± 1.7 fL, P 〈0.001 ） and Group 2 （8.0 ± 1.4 fL,P =0.006）. Linear regression analysis showed that low levels of vitamin D （r2 =0. 337 ,P 〈0.001 ） was independently associated with increased MPV. Conclusion The vitamin D level is closely related with MPV. The vitamin D deficiency would results in a higher MPV.