乙型肝炎患者抗HBc-IgM与ALT的相关性分析

The correlation analysis between anti-HBc-IgM and ALT in patients with hepatitis B

目的探讨乙型肝炎患者抗HBc-Ig M与谷丙转氨酶(ALT)的相关性。方法分别检测乙肝患者血清标志物(HBs Ag、HBs Ab、HBe Ag、HBe Ab、HBc Ab-Ig G及Ig M)和ALT,并分析其相关性。结果在HBs Ag+HBe Ag+HBc Ab、HBs Ag+HBe Ab+HBc Ab和HBs Ag+HBc Ab模式中,ALT在抗HBc-Ig M阳性与阴性患者中的分布差异有统计学意义(P<0.05);在抗HBc-Ig M阳性患者中,ALT在HBs Ag+HBe Ag+HBc Ab、HBs Ag+HBe Ab+HBc Ab、HBs Ag+HBc Ab模式中的分布情况分别是70(68)、31(41)、48(106)U/L,差异有统计学意义(P<0.05)。在抗HBc-Ig M阴性患者中,ALT在三种乙肝模式中分别是39(17)、24(20)、21(23)U/L,HBs Ag+HBe Ag+HBc Ab模式分别与HBs Ag+HBe Ab+HBc Ab及HBs Ag+HBc Ab模式的ALT分布差异有统计学意义(P<0.05);HBs Ag+HBe Ab+HBc Ab模式与HBs Ag+HBc Ab模式ALT分布差异无统计学意义(P>0.05);在三种乙肝模式中,抗HBc-Ig M阳性率在ALT正常与异常中的分布差异有统计学意义(P<0.05)。结论在HBs Ag+HBe Ag+HBc Ab、HBs Ag+HBe Ab+HBc Ab、HBs Ag+HBc Ab乙肝患者中,抗HBc-Ig M与ALT具有一定的相关性,两者对判断乙肝患者肝脏损伤情况以及了解病情具有一定的临床意义。

Objective To investigate the correlation between anti-HBc-Ig M and ALT in patients with hepatitis B. Methods HBs Ag, HBs Ab,HBe Ag,HBe Ab, HBc Ab-Ig G, HBc Ab-Ig M and ALT of hepatitis B patients were detected and analyzed for their correlation. Results Among HBs Ag ＋HBe Ag ＋HBc Ab, HBs Ag ＋HBe Ab ＋HBc Ab and HBs Ag ＋HBc Ab, the distribution of ALT between the HBc Ab-Ig M positive group and negative group has significant difference（P 〈0.05）. In HBc Ab-Ig M positive group, the distributions of ALT among HBs Ag ＋HBe Ag ＋HBc Ab,HBs Ag ＋HBe Ab ＋HBc Ab and HBs Ag ＋HBc Ab are 70（68）, 31（41）, and 48（106）U / L, respectively; the distributions among the three groups are also significant different（P 〈0.05）. In HBc Ab-Ig M negative group, the distributions of ALT among HBs Ag＋HBe Ag＋HBc Ab, HBs Ag＋HBe Ab＋HBc Ab and HBs Ag＋HBc Ab are 39（17）, 24（20）, and 21（23）U / L, respectively. There is significant difference between HBs Ag ＋HBe Ag ＋HBc Ab and HBs Ag ＋HBe Ab ＋HBc Ab with the distribution of ALT（P 〈0.05）. The distribution of ALT between HBs Ag ＋HBe Ag ＋HBc Ab and HBs Ag ＋HBc Ab is also significant different（P〈0.05）. But the distribution between HBs Ag ＋HBe Ab ＋HBc Ab and HBs Ag ＋HBc Ab is not significant different,（P 〉0.05）. Among the three groups of hepatitis B which stated before, the positive rate of HBc Ab-Ig M is significant different from the normal ALT group to the ALT abnormal group（P 〈0.05）. Conclusion Among the hepatitis B of HBs Ag ＋HBe Ag ＋HBc Ab,HBs Ag ＋HBe Ab ＋HBc Ab and HBs Ag ＋HBc Ab, HBc Ab-Ig M and ALT are correlated. They are both important markers for doctors to estimate the condition of the liver damage of the patients with hepatitis B and the status of the illness.