妊娠期高血压疾病尿微量白蛋白/肌酐比值与24h尿蛋白定量的相关性

The correlation between spot urinary microalbumin/creatinine ratio and 24h urinary protein excretion in women with hypertensive disorders complicating pregnancy

目的探讨妊娠期高血压疾病孕妇随机尿中尿微量白蛋白/肌酐比值(UACR)与24 h尿蛋白定量之间的相关性。方法选取2013年1-12月东莞市厚街医院收治的妊娠期高血压疾病孕妇143例,采用免疫比浊法检测孕妇的24 h尿蛋白定量,采用自动生化分析仪检测UACR,再进行二者的相关性分析。结果从妊娠期高血压到轻度子痫前期再到重度子痫前期孕妇UACR和24 h尿蛋白定量均逐渐升高,三组比较差异有统计学意义(P均<0.05)。UACR与24 h尿蛋白定量呈密切正相关(r=0.898,P<0.05)。结论随机UACR有望代替24 h尿蛋白定量评估子痫前期病情严重程度。

Objective To analyze the correlation between random urinary microalbumin / creatinine ratio and 24 h urinary protein excretion in women with hypertensive disorders complicating pregnancy. Methods There were 143 cases with hypertensive disorders complicating pregnancy from January to December in 2013. Twenty-four hours urinary protein excretion was measured by immunotnrbidimetric assay and microalbumin / creatinine ratio was determined by automatic analyzer. Results Urinary albumin / creatinine ratio and 24 h urinary protein increased gradually from pregnancy induced hypertension to mild and severe preeclampsia,with significant differences（P〈0.05）. There was a strong correlation between the microalbumin / creatinine ratio and 24 h urine protein excretion（r =0.898,P 〈0.05）. Conclusion Microalbumin /creatinine ratio may be used as a replacement for 24 h urinary protein excretion in assessment of preeclampsia.