影响正常眼压性青光眼的血管因素研究

Effect of vascular factors on normal tension glaucoma

目的观察血管因素对正常眼压性青光眼(NTG)的影响。方法前瞻性地对NTG组40眼及年龄、性别相匹配的正常对照组40眼行彩色超声多普勒成像(CDFI)研究,分析颈总动脉(CA)、颈内动脉(ICA)、眼动脉(OA)、视网膜中央动脉(CRA)和睫状后短动脉(SPCA)的收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)及阻力指数(RI)。结果 NTG组ICA、OA、CRA、SPCA的PSV与正常对照组比较均降低(P<0.01、P<0.05),RI则明显增高(P<0.01),OA和CRA的EDV与正常对照组比较亦均降低(P<0.01、P<0.05),ICA和SPCA的EDV与正常对照组比较差异无统计学意义(P>0.05),而CA的各项参数与正常对照组比较差异亦均无统计学意义(P>0.05)。结论应将ICA、OA、CRA、PCA的RI增高作为早期诊断NTG及判断预后的重要指标,同时亦应参考OA、CRA的EDV是否降低,以对NTG患者的预后及治疗方案提供有利信息。

Objective To observe the effect of vascular factors on normal tension glaucoma（NTG）.Methods The NTG group of 40 eyes,and the age and sex matched normal control group of 40 eyes were enrolled in this study.Color Doppler flow image （CDFI）was used to analyze the peak systolic velocity（PSV）,the end diastolic velocity（EDV） and the resistance index（RI）of the carotid artery（CA）,the internal carotid artery（ICA）,the ophthalmic artery（OA）, the central retinal artery（CRA）and the shortposterior ciliary artery（SPCA）.Results The PSV of ICA,OA,CRA and SPCA in the NTG group was decreased （P〈0.01,P〈0.05）and RI was significantly increased （P〈0.01）.The EDV of OA and CRA in the NTG group compared with the normal control group was decreased （P〈0.01,P〈0.05）, while the EDV of ICA and SPCA in the NTG group compared with the normal control group showed no significant difference （P〉0.05）,and the parameters of CA in the NTG group compared with the normal control group showed no significant difference （P〉0.05）.Conclusion The increasing RI of ICA,OA,CRA and PCA should be used as important indicators in the early diagnosis and judgment prognosis of NTG,and should also be referred to if the EDV numerical value of OA and CRA is decreased,to provide favorable information for judgment prognosis and treatment project of NTG patients.