自噬与动脉粥样硬化的关系及中药的干预作用

Relationship Between Autophagy and Atherosclerosis and Modulation of Traditional Chinese Medicine

自噬是由溶酶体介导的降解胞质内受损的细胞器或蛋白质的代谢过程。适度的自噬对动脉粥样硬化具有保护作用,过度的自噬却会导致细胞死亡,不利于斑块的稳定性。中药能通过多途径、多靶点整合起效防治动脉粥样硬化,其机制很可能与调控动脉粥样硬化相关细胞自噬有关。本文就自噬在动脉粥样硬化中的双重作用、调控自噬对干预动脉粥样硬化的意义、中药对自噬的影响及其在动脉粥样硬化防治中的潜在意义作一综述。

Autophagy is a metabolic process for the degradation of damaged organelles or proteins in the cytoplasm via the lysosomal system. A moderate amount of autophagy has a protective effect for atherosclerosis,but excessive autophagy can lead to cell death that is not conducive to the stability of the plaque. Traditional Chinese medicine can prevent and treat atherosclerosis through many channels and multiple targets integration,which mechanism is probably related to the regulation of atherosclerosis cell autophagy. This paper is to summarize the dual role of autophagy in atherosclerosis,regulation of autophagy on the significance of intervention of atherosclerosis,the influence of traditional Chinese medicine of autophagy and its potential significance in the prevention of atherosclerosis.