期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

动脉粥样硬化中巨噬细胞增殖调控的研究进展 被引量：3

Research Progress of Regulation of Macrophage Proliferation in Atherosclerosis
下载PDF
导出
摘要 巨噬细胞是机体免疫系统的重要组成部分,在动脉粥样硬化及相关的心血管疾病中发挥至关重要的作用。传统观点认为巨噬细胞来源于血液单核吞噬系统并不可再生,但新近研究表明组织内巨噬细胞具有增殖能力并发挥关键作用。目前已知细胞周期调节物、骨髓生长因子和氧化型低密度脂蛋白与动脉粥样硬化中巨噬细胞增殖关系密切。本文就动脉粥样硬化中巨噬细胞增殖调控加以综述。 Macrophage,an important component of the immune system,plays a crucial role in atherosclerosis and related cardiovascular diseases. Conventional wisdom holds that macrophages are derived from blood mononuclear phagocytic system and not renewable,but recent studies have shown that tissue macrophage can proliferate and has played a key role. Cell cycle regulators,bone growth factors and oxidized low density lipoprotein are closely related with macrophages in atherosclerosis. This article briefly reviews regulation of macrophage proliferation in atherosclerosis.
作者 张欣 张晓卉 尹新华
机构地区 哈尔滨医科大学附属第一医院心血管内科
出处 《中国动脉硬化杂志》 CAS CSCD 北大核心 2014年第9期961-964,共4页 Chinese Journal of Arteriosclerosis
基金 国家自然科学基金项目(81370319)
关键词 动脉粥样硬化 巨噬细胞 细胞增殖 Atherosclerosis Macrophages Cell Proliferation
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献32

  • 1Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030[J]. PLoS Med, 2006, 3 : e442.
  • 2Murray PJ, Wynn TA. Protective and pathogenic functions of macro- phage subsets[J]. Nat Rev Immunol, 2011, 11 : 723-737.
  • 3Fuster JJ, Fernandez P, Gonzalez-Navarro H, et al. Control of cell proliferation in atherosclerosis : insights from animal model and hu- man studies[J]. Cardiovasc Res, 2010, 86: 254-264.
  • 4Moore KJ, Tabas I. Macrophages in the pathogenesis of atherosclero- sis[J]. Cell, 2011, 145: 341-355.
  • 5姜怡邓,杨安宁,王菊,巩慧慧,马长剑,杨晓玲,李桂忠.高同型半胱氨酸血症对ApoE^(―/―)鼠心肌酶谱的影响及与P53基因的相关性分析[J].中国动脉硬化杂志,2013,21(1):16-21. 被引量：9
  • 6仲英洁,张子为,徐郁,花晓敏,胡云.阿托伐他汀对ApoE^(-/-)小鼠主动脉粥样硬化和钙化的影响[J].中国动脉硬化杂志,2013,21(4):305-310. 被引量：13
  • 7Butcher M J, Galkina EV. Phenotypie and functional heterogeneity of macrophages and dendritic cell subsets in the healthy and atheroscle- rosis-prone aorta[ J]. Front Physiol, 2012, 3:44.
  • 8Lee CW, Hwang I, Park CS, et al. Macrophage heterogeneity of culprit coronary plaques in patients with acute myocardial infarction or stable angina[J]. Am J Clin Pathal, 2013, 139(3) : 317-322.
  • 9Laufer EM, Winkens MH, Narula J, et al. Molecular imaging of macrophage cell death for the assessment of plaque vulnerability [ J]. Arterioseler Thromb Vasc Biol, 2009, 29 : 1 031-038.
  • 10Jenkins S J, Ruckerl D, Cook PC, et al. Local macrophage prolif- eration, rather than recruitment from the blood, is a signature of TH2 inflammation[J]. Science, 2011,332:1 284-288.

二级参考文献29

  • 1Detrano RC, Wong ND, Doherty TM,et al. Prognostic significance of coronary calcific deposits in asymptomatic high-risk subjects [J] . Am J Med, 1997,102: 344-349.
  • 2Goodman WG, Goldin J, Kuizon BD, et al . Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis [ J]. N Engl J Med, 2000, 342: 1 478-483.
  • 3Wagenknecht LE, Bowden DW, Carr JJ, et al. Familial aggregation of coronary artery calcium in families with type 2 diabetes [ J ]. Diabetes, 2001, 50: 861-866.
  • 4Mohler ER III, Gannon F, Reynolds C, et al. Bone formation and inflammation in cardiac valves [J]. Circulation, 2001, 103: 1 522- 528.
  • 5Cowell SJ, NewbyDE, Prescott RJ, et al. Arandomizedtrial of intensive lipid-lowering therapy in calcific aortic stenosis [ J ]. N Engl J Med, 2005, 352 (23) : 2 389-397.
  • 6Raison J, Rudnichi A, Safar ME. Effects of atorvastatin on aortic pulse wave velocity in patients with hypertension and hypercholesterolaemia , a preliminary study [ J ]. J Hum Hypertens 2002, 16: 705-710.
  • 7Luigi Giusto Spagnoli, Elena Bonanno, Giuseppe Sangiorgi, et al. Role of Inflammation in Atherosclerosis [ J]. J N ucl Med, 2007, 48: 1 800-815.
  • 8Joseph Shalhoub, Mika A Falck-Hansen, Alun H Davies, et al. Innate immunity and monocyte-macrophage activation in atherosclerosis[J]. Journal of Inflammation, 2011, 8(9): 1-17.
  • 9Chang K, Weiss D, Suo J, Vega JD, Giddens D, Taylor WR, Jo H. Bone morphogenic protein antagonists are coexpressed with bone morphogenic protein 4 in endothelial cells exposed to unstable flow in vitro in mouse aortas and in human coronary arteries: role of bone morphogenic protein antagonists in inflammation and atherosclerosis [ J ]. Circulation, 2007, 116: 1 258 -266.
  • 10Yao Y, Bennett BJ, Wang X, et al. Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification [ J]. Circ Res, 2010, 107: 485-494.

共引文献20

同被引文献30

  • 1丘创华,侯敢,黄迪南.TNF-α信号传导通路的分子机理[J].中国生物化学与分子生物学报,2007,23(6):430-435. 被引量：76
  • 2Wang FP, Gao QP, Guo SY, et al. The sonodynamic effect of curcumin on THP -1 cell-derived macrophages [ J]. Biomed Res Int , 2013, 2013: 737 264.
  • 3Shibaguchi H, Tsuru H, Kuroki M. Sonodynamic cancer therapy: a non-invasive and repeatable approach using low-intensity ultrasound with a sonosensitizer [ J J. Anticancer Res, 2011, 31 ( 7 ): 2 425-429.
  • 4Rosenthal I, Sostaric JZ, Riesz P. Sonodynamic therapy: a review of the synergistic effects of drugs and ultrasound [ J ]. Ultrason Sonochem, 2004, 11(6): 349-363.
  • 5Lv Y, Fang M, Zheng J, et al. Low-intensity ultrasound combined with 5-aminolevulinic acid administration in the treatment of human tongue squamous carcinoma [ J]. Cell Physiol Biochem, 2012, 30 (2) : 321-333.
  • 6Krammer B, Plaetzer K. ALA and its clinical impact, from bench to bedside [ J]. Photochem Photobiol Sci, 2008, 7: 283-289.
  • 7Sharma S, Jajoo A, DUM A. 5-Aminolevulinic acid-induced protoporphyrin- IX accumulation and associated phototoxicity in macrophages and oral cancer cell lines [ J]. J Photochem Photobiol B, 2007, 88: 156-162.
  • 8Agostinis P, Berg K, Cengel KA, et al. Photodynamic therapy of cancer: an update[J]. CA Cancer] Clin, 2011, 61(4): 250-281.
  • 9Moore KJ, Tabas I. Macrophages in the pathogenesis of atherosclerosis[ J]. Cell, 2011, 145: 341-355.
  • 10Ley K, Miller YI, Hedrick CC. Monocyte and macrophage dynamics during atherogenesis [ J] . Arterioscler Thromb Vase BioI, 2011, 31: 1 506-516.

引证文献3

二级引证文献5

中国动脉硬化杂志
2014年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部