巨噬细胞增殖和凋亡与动脉粥样硬化

Macrophage Proliferation and Apoptosis on Atherosclerosis

动脉粥样硬化(As)是一种由动脉壁脂质沉积所引发的一种病理生理过程,与巨噬细胞介导的慢性炎性反应高度相关。As早期,巨噬细胞通过吞噬作用清除斑块中修饰脂蛋白、细胞碎片和死亡细胞,限制斑块生长。随着病程进展,斑块中巨噬细胞凋亡增多且清除功能下降,引起继发性细胞坏死和炎性反应,促成不稳定斑块形成。巨噬细胞增殖和凋亡与As发生发展密切相关。本文主要针对巨噬细胞增殖和凋亡对As发生发展的影响做一综述,为As防治提供理论依据。

Atherosclerosis（As） is a pathological and physiological process triggered by lipid deposition in arterial wall,and is highly correlated with chronic inflammatory reaction mediated by macrophages. In early stage of atherosclerosis,macrophage limits disease progression by phagocytizing modified lipoproteins,cellular debris and dead cells. As the disease progresses,macrophages apoptosis increases and efferocytosis defective causes the secondary necrosis and inflammatory reaction,thus promotes the formation of unstable plaques. Macrophage proliferation and apoptosis are closely related to atherosclerosis. Therefore,this article focuses on macrophage proliferation and apoptosis on atherosclerosis,providing the theoretical basis for atherosclerosis prevention and control.