期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

miRNA对血管内皮细胞功能调节的研究进展 被引量：5

Advances in miRNA Regulating Function of Human Endothelial Cell
下载PDF
导出
摘要 miRNA是一类长约18~24个核苷酸的高度保守性的小分子非编码RNA,主要通过与特异性靶基因miRNA 3’-UTR区结合来调控基因的表达。miRNA与细胞增殖、分化、凋亡、胚胎发育、组织器官等形成以及多种疾病的发生发展密切相关。新近研究显示,内皮型miRNA对心血管内皮细胞生理功能具重要的调节作用。本文就miRNA对血管内皮细胞功能调节的研究进展作一概述。 miRNAs are a class of highly conserved small molecules of about 18 ~ 24 nucleotides non-coding RNAs regulating gene expression by binding to the specific target gene mRNA 3’-UTR. It has been shown that miRNAs are related to the process of cell proliferation,differentiation,apoptosis,embryonic development,tissue and organ formation as well as the development of a variety of diseases. Recently,studies have shown that some miRNAs play an important role in regulation function of human endothelial cell. In this review,we focus on discussing miRNAs’ role in the regulation function of human endothelial cell.
作者 李玉媚 欧和生
机构地区 广西医科大学药学院
出处 《中国动脉硬化杂志》 CAS CSCD 北大核心 2014年第10期1072-1076,共5页 Chinese Journal of Arteriosclerosis
基金 国家自然科学基金面上项目(81373403) 广西硕士研究生科研创新项目(YCSZ2013031)
关键词 MIRNA 血管内皮细胞 基因表达 miRNA Vascular Endothelial Cell Gene Expression
分类号 Q752 [生物学—分子生物学]
  • 相关文献

参考文献34

  • 1Lee RC, Feinbaum RL, Ambros V. The C elegans hetero chronic gene lin-4 encodes small RNAs with antisense com- plementarity to lin-14 [ J ]. Cell, 1993, 75 (5) : 843-854.
  • 2Reinhart B J, Slack FJ, Basson M, et al. The nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans [ J ]. Nature, 2000, 403 (6772) : 901-906.
  • 3Barrel DP. MicroRNAs: target recognition and regulatory functions[J]. Cell, 2009, 136 (5) : 215-233.
  • 4Liu X, Cheng Y, Zhang S, et al. A necessary role of miR- 221 and miR-222 in vascular smooth muscle cell prolifera- tion and neointimal hyperplasia[ J ]. Circ Res, 2009, 104 (32) : 476-487.
  • 5Chen Y, Banda M, Speyer CL, et al. Regulation of the ex- pression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221 [J]. Mot Cell Biol, 2010, 30 (7) : 3 902-913.
  • 6Nicoli S, Knyphausen CP, Zhu LJ, et al. miR-221 is re- quired for endothelial tip cell behaviors during vascular de- velopment[J]. Dev Cell, 2012, 22 (19): 418-429.
  • 7Martin MM, Lee EJ, Buckenberger JA, et al. miRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts[J]. J Biol Chem, 2006, 281 (27) : 18 277- 284.
  • 8Zhu N, Zhang D, Chen S, miRNAs regulate angiotensin flammation and migration[ J]. (2) : 286-293.
  • 9et al. Endothelial enriched lI-induced endothelial in- Atherosclerosis, 2011, 215 Fichtlscherer S, De Rosa S, Fox H, et al. Circulating miRNAs in patients with coronary artery disease [ J ]. Circ Res, 2010, 107 (5): 677-684.
  • 10Qin B, Xiao B, Liang D, et al. MicroRNAs expression in ox-LDL treated HUVECs: MiR-365 modulates apoptosis and Bcl-2 expression [ J ]. Biochem Biophys Res Com- mun, 2011, 410 (1) : 127-133.

二级参考文献39

  • 1Lee RC, Feinbaum RL, Ambros V, et al. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J]. Cell, 1993, 75(5) : 843-854.
  • 2Liang M, Liu Y, Mladinov D, et al. MicroRNA : A new frontier in kidney and blood pressure research[ J]. Am J Physiol Renal Physiol, 2009, 297(3) : F553-F558.
  • 3Tabara H, Sarkissian M, Kelly WG. The rde-1 gene, RNA interference, and transposon silencing in C. elegans [ J]. Cell, 1999, 99(2) : 123-132.
  • 4Brennecke J, Stark A, Russell RB, et al. Principles of microRNA- target recognition [ J ]. PLoS Biol, 2005, 3 (3) : e85.
  • 5Pillai RS, Bhattacharyya SN, Filipowicz W. Repression of protein synthesis by miRNAs: how many mechanisms? [ J ]. Trends Cell Biol, 2007, 17(3) : 118-126.
  • 6Zhang MX, Ou H, Shen YH, et al. Regulation of endothelial nitric oxide synthase by small RNA [ J ]. Proc Natl Acad Sci USA, 2005, 102(47): 16967-16972.
  • 7Brennecke J, Hipfner DR, Stark A, et al. bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotie gene hid in drosophila [ J ]. Cell, 2003, 113(1) : 25-36.
  • 8Douglas LM. MicroRNAs and the failing heart [ J ] . N Engl J Ned, 2007, 356(25) : 2644-2645.
  • 9Thum T, Galuppo P, Wolf C, et al. MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure [ J ]. Circulation, 2007, 116 (3) : 258-267.
  • 10Ikeda S, He A, Kong SW, et al. MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes[J]. Mol Cell Biol, 2009, 29(8) : 2193-2204.

共引文献11

同被引文献24

引证文献5

二级引证文献13

中国动脉硬化杂志
2014年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部