浙江省肿瘤登记地区鼻咽癌发病与死亡现状及趋势分析

Analysis of the status and trend of nasopharyngeal carcinoma incidence and mortality in cancer registries of zhejiang province

目的研究浙江省肿瘤登记地区2000～2009年鼻咽癌发病与死亡的流行状况及趋势。方法鼻咽癌发病与死亡数据来源于浙江省6个肿瘤登记地区,并经浙江省癌症中心审核、整理和统计分析,计算粗率、标化率及变化趋势。结果 2000～2009年浙江省肿瘤登记地区鼻咽癌粗发病率和粗死亡率分别为4.47/10万和1.82/10万,中标率分别为2.64/10万和0.95/10万,占全部癌症新发病例和死亡病例的1.65%和1.15%。鼻咽癌年龄别发病率在20岁之前处于较低水平,在60～64岁组达到高峰,为10.90/10万,年龄别死亡率在35岁之前处于较低水平,在80～84岁组达到高峰,为8.76/10万。2000～2009年浙江省鼻咽癌发病率呈现波动增长趋势,2002年最低为3.26/10万,2005年最高为4.88/10万,年度变化百分比（APC）为4.04%（95%CI为1.08%～7.08%）,鼻咽癌死亡率则呈现波动下降趋势。结论浙江省鼻咽癌发病率介于高发区与低发区之间,且发病率呈现增长趋势,提示应进一步开展分析流行病学调查,研究其病因和防治对策。

OBJECTIVE To investig te epidemiology characteristics and trends of nasopharyngeal carcinoma（NPC） incidence and mortality in Zhejiang cancer registration areas from 2000 to 2009. METHODS Cancer registration data were collected from 6 cancer registries of Zhejiang province. The data were checked, sorted and analyzed by Zhejiang Cancer Center. The crude rate, proportions, age standardized rates, cumulate rates, cut rates, age-specific rates and Annual Percentage Change（95%CI） of NPC were calculated. RESULTS The crude incidence rate and the mortality rate of NPC were 4.47/100,000 and 1.82/100,000 between 2000 and 2009 in Zhejiang, the age-standardized by Chinese population were 2.64/100,000 and 0.95/100,000, accounted for 1.65% of new cancer cases and 1.15% of all deaths cases. Age-specific incidence of NPC remained low before 20 years old, and peaked at 60-64 years old age group（10.09/100,000）. Agespecific mortality of NPC remained low before 35 years old, and peaked at 80～84 years old age group（8.76/100,000）. The annual NPC incidence rate increased fluctuatedly between 2000 and 2009 in Zhejiang, stayed the lowest level in 2002（3.26/100,000） and reached the highest level in 2005（4.88/100,000）, the Annual Percent Change（APC） is 4.04%（95%CI=1.08%-7.08%, statistical significance）, meanwhile, the annual NPC mortality rate declined f luctuatedly. CONCLUSION The incidence of NPC in Zhejiang was between the high and low incidence areas and had a growth trend,which indicates that further epidemiological study and prevention for NPC should be strengthened.