男性偏执型精神分裂症患者脑白质网络连接强度与病程相关性

The strength of the nodes of the brain white matter weighted networks and its relationship with the course of disease in male schizophrenia

目的探讨男性偏执型精神分裂症患者与男性正常对照者脑白质结构加权网络节点连接强度属性值的异同,分析患者不同脑区的连接纤维受损情况及其与病程的关系。方法对25例男性偏执型精神分裂症患者及26例男性对照者进行弥散张量成像扫描(diffusion tensor imaging,DTI),利用解剖学自动标记(auto-mated anatomical labeling,AAL)模板将大脑划分为90个区域,采用确定性纤维追踪(fiber assignment by continu-ous tracking,FACT)方法进行纤维追踪,构建脑白质结构加权网络。结果患者组右侧丘脑(P=0.03,校正后)、右侧颞横回(P=0.04,校正后)连接强度属性值较对照组下降。患者组右侧丘脑连接强度属性值与病程呈负相关(r=-0.45,P=0.03)。结论男性偏执型精神分裂症患者连接纤维受损的脑区主要位于丘脑和颞叶;同时,丘脑连接纤维的损害与病程有关。

Objective To explore the differences in the strength of the nodes in the brain white matter weighted networks between the male patients with paranoid schizophrenia and male healthy controls, and to analysis the integrity of the white matter fiber tracts that connected to the different brain regions and its relationship with the course of disease. Methods Diffusion tensor imaging （DTI） data were obtained from 25 male patients with paranoid schizophrenia and 26 male healthy controls. The whole brain was parcellated into 90 regions by using the anatomical label map. Tractography was performed in the whole brain of each subject to reconstruct white matter tracts using the FACT algorithm. The brain white matter weighted networks were then constructed using the complex network theory. Results The strength of the nodes in the networks of schizophrenia significantly decreased in the right thalamus （P=0.03, corrected） and the right hes？chl gyrus （P=0.04, corrected）. Negative correlation was found between the strength of the right thalamus and the course of disease （r=-0.45, P=0.03）. Conclusion The integrity of the white matter fiber tracts connected to the thalamus and tem？poral lobes in the male paranoid schizophrenia is impaired. The lesion of fiber tracts connected to the thalamus is related with the course of disease.