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流感病毒神经氨酸酶抑制剂的研究进展

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摘要 流感病毒在感染和传播过程中,神经氨酸酶(NA)起到了关键作用,因此,神经氨酸(即唾液酸)已成为设计、合成流感病毒神经氨酸酶抑制剂(NAIs)的重要先导化合物和模版分子。文中综述了抗流感病毒唾液酸类NAIs的研究进展。
作者 李璟 陈 孙雅博 黄永茂 范继业
机构地区 河北化工医药职业技术学院
出处 《华西药学杂志》 CAS CSCD 2015年第1期113-116,共4页 West China Journal of Pharmaceutical Sciences
关键词 唾液酸 神经氨酸酶 抑制剂 流感 病毒 合成 研究进展 综述
分类号 R914 [医药卫生—药物化学]
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参考文献36

  • 1黄兰,周剑芳,韦红,舒跃龙.流感病毒神经氨酸酶抑制剂药物耐药现状及机制研究进展[J].病毒学报,2012,28(5):572-576. 被引量：24
  • 2Calfee D, Hayden F. New approaches to influenza chemotherapy neuraminidase inhibitors [ J ]. Drugs, 1998,56 (4) :537 - 553.
  • 3Meindl P, Bodo G, Lindner J, et al. Einfluss yon 2 - desoxy - 2,3 - dehydro - N - acetylneuramins ure auf myxovirus - neura- minidasen und die replikation yon influenza- und newcastle disease virus[ J]. Z Narurforsch B ,1971,26(8) :792-797.
  • 4Goodford PJ. A computational procedure for determining energeti- cally favorable binding sites on biologically important macromole- cules [J]. J Med Chem,1985,28(7) :849 -857.
  • 5Kim CU, Lew W, Williams MA, et al. Design, synthesis, and structural analysis of carbocyelic sialic acid analogues with potent anti - influenza activity [ J ]. J Am Chem Soc, 1997,119 (4) : 681 - 690.
  • 6Marek JJ, Singh S, Brouillette W J, et al. Struetures of aromatic inhibitors of influenza virus neuraminidase [ J ]. Biochemistry, 1995,34(10) :3144 -3151.
  • 7Williams M, Bischofberger N, Swaminathan S, et al. Synthesis and influenza neuraminidase inhibitory activity of aromatic ana- logues of sialic acid[ J ]. Bioorg Med Chem Lett, 1995,5 (19) : 2251 - 2254.
  • 8Singh S,Jedrzejas MJ, Air GM, et al. Structure -based inhibi- tors of influenza virus sialidase. A benzoic acid lead with novel interaction[ J]. J Med Chem, 1995, 38 (17) : 3217 - 3225.
  • 9Chand P, Babu YS, Bantia S, et al. Design and synthesis ofbenzoic acid derivatives as influenza neuraminidase inhibitors using structure - based drug design[J]. J Med Chem, 1997,40 (25) :4030 -4052.
  • 10Atigadda VR, Brouillette WJ, Duarte F, et al. Potent inhibition of influenza sialidase by a benzoic acid containing a 2 - pyrmli- dine substituent [ J ]. J Med Chem, 1999,42 ( 13 ) :2332 - 2343.

二级参考文献28

  • 1Von Itzstein M, Wu W Y, Kok G B, et al. Rational de- sign of potent sialidase-based inhibitors of influenza viru1 replication[J]. Nature,1993,363(6428) :418-423.
  • 2Kim C U, Lew W, Williams M A, et al. Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid ana- logues with potent anti-influenza activity [J]. J Am Chem Soc,1997,119(4) :681-690.
  • 3Ikematsu H, Kawai N. Laninamivir octanoate., a new long-acting neuraminidase inhibitor for the treatment of influenza[J]. Expert Rev Anti Infect Ther,2011,9(10): 851-857.
  • 4Stoner T D, Krauss S, Dubois R M, et ai. Antiviral susceptibility of avian and swine influenza virus of the N1 neuraminidase subtype[J]. J Virol, 2010,84 (19) 9800-9809.
  • 5Chen H, Cheung C L, Tai H, et al. Oseltamivir-resist- ant influenza A pandemic (H1N1) 2009 virus, Hong Kong, China[J]. Emerg Infect Dis,2009,15(12):1970- 1972.
  • 6Le Q M, Wertheim H F, Tran N D, et al. A communi ty cluster of oseltamivir-resistant cases of 2009 ttlN1 influenza[J]. N Engl J Med,2010,362(1):86-87.
  • 7Le Q M, Kiso M, Someya K, et al. Avian flu: isolation of drug-resistant HSN1 virus [J]. Nature, 2005, 437 (7062) : 1108-1108.
  • 8Monto A S, Mckimm-Breschkiaa J L, Macken C, et al. Detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first 3 years of their use[J]. Antimierob:gents Chemother, 2006,50 (7) :2395-2402.
  • 9Nguyen H T, Fry A M, Gubareva L V. Neuraminidase inhibitor resistance in influenza viruses and laboratory testing methods[J]. Antivir Ther, 2012,17(1 Pt B): 159-173.
  • 10Abed Y, Baz M, Boivin G. Impact of neuraminidase mutations conferring influenza resistance to neuramini- dase inhibitors in the N1 and N2 genetic backgrounds. [J]. Antivir Ther,2006,11(8) : 971-976.

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2015年 第1期

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