舒血宁注射液辅助治疗冠心病不稳定性心绞痛有效性系统评价

Meta-Analysis of Therapy Plan Assisted by Shuxuening Injection on Coronary Heart Disease with Unstable Angina Pectoris

目的:系统评价舒血宁注射液治疗冠心病不稳定性心绞痛的有效性。方法:检索CNKI、万方、VIP、CMB以及Cochrane library、Pubmed、Embase网站,全面收集舒血宁注射液治疗不稳定性心绞痛所有类型的临床研究。纳入随机/半随机对照试验,采用Revman 5.2软件进行统计分析。结果:共纳入24个研究2371例不稳定心绞痛的随机/半随机对照研究。症状加硝酸甘油用量方面,6项研究的2个亚组分析均有统计学意义(RR值为1.23和1.37)。心电图改善方面,11项研究的4个亚组分析均有统计学意义(RR值分别为1.29、1.25、1.24、1.56),未发现严重的不良反应/不良事件。结论:常规治疗基础上加用舒血宁注射液,可降低心绞痛症状和硝酸甘油用量,改善心电图表现,提示其能进一步减轻心肌缺血的状况,且临床应用较为安全。

Objective： To evaluate the efficacy of therapeutic plan assisted by Shuxuening Injection by systemic review. Method： The randomized controlled trials （RCTs） and quasi-RCTs of basic therapeutic plan recommended by guidelines combined with Shuxuening Injection on patients with Unstable Angina Pectoris were searched in China National Knowledge Internet （CNKI）, Wanfang database, China Biology Medicine （CBM）, VIP database, Cochrane library, Pubmed and Embase. The Cochrane handbook Scale was used to extract the data and Revman 5.2 software was adopted to analyze them. Result： In this study, 28 RCT or quasi-RCT studies with 2671 case involving Unstable Angina Pectoris was included. For analysis on attack frequency of Angina Pectoris plus consumption of nitroglycerin, 2 subgroups from 6 researches both showed significant difference and their RR value were 1. 23 and 1.37. As for ECG improvement analysis, 4 subgroups from 11 researches all indicated statistical significance and their exact data was 1.29, 1.25, 1.24, 1~56 respectively. None serious adverse effect/event was found. Conclusion： It is effective to alleviate symptoms of Angina Pectoris as well as reduce dose of nitroglycerin, improve Electrocardiogram result by adding Shuxuening Injection to basic therapy plan which indicate that it further relieve the ischemic situation of myocardial muscle. Moreover, it is safety in clinical application.