甾体类肌松药物拮抗剂布瑞亭临床应用的研究进展

Research progress in clinical application of sugammadex as a reversal agent for steroidal muscle relaxants

背景布瑞亭是选择性甾体类肌松药物拮抗剂，可以快速、安全、有效地拮抗罗库溴铵等甾体类肌松药物的肌松作用。近年来，随着麻醉医师对肌松药可控性要求的提高，布瑞亭的应用与研究也随之增多。目的介绍近年来布瑞亭的临床应用进展，有助于探索此药在肌松拮抗领域的合理应用。内容对布瑞亭的药理学特性、临床应用、在特殊人群中的应用、禁忌证和副作用等进行综述。趋向布瑞亭在拮抗甾体类肌松药物方面将具有广泛的应用前景，布瑞亭与罗库溴铵的组合有可能会取代琥珀胆碱的位置。

Background Sugammadex is a selective reversal agent for steroidal muscle relaxants, which can rapidly, safely, and efficiently antagonize the steroidal muscle relaxants, such as rocuronium. Its research and application increased in recent years along with the higher requirement in controllability of muscle relaxation. Objective This review focuses on introducing the research progress in clinical application of sugammadex, and provides guidance for its reasonable clinical application in muscle relaxants reversal. Content To review the pharmacology, clinical application, its use in special patient populations, contraindications and adverse effects of Sugammadex. Trend Sugammadex will have broad application prospects in muscle relaxants＇ reversal and the combination application of Sugammadex and rocuronium will have the potential to replace succinylcholine.