尼克酰胺磷酸核糖转移酶对心肌缺血／再灌注的影响研究进展

The research advance of the potential role of nicotinamide phosphoribosyltransferase in myocardial ischemic/reperfusion injury

背景尼克酰胺磷酸核糖转移酶（nicotinamide phosphoribosyltmnskmse，NAMPT）是合成烟酰胺腺嘌呤二核苷酸（nicotinamide adenine dinucleotide，NAD）的限速酶。NAMPT可存在干细胞内和细胞外，它们的作用不尽相同。NAMPT在心血管系统中发挥着重要作用，但在心肌缺血，再灌注（ischemia／reperfusion，I／R）中的作用尚存争议。目的进一步了解NAMPT的心血管作用及对心肌I/R的影响。内容就目前研究对NAMPT的来源及潜在的心血管作用、细胞内NAMPT（intracellular NAMPT，iNAMPT）及细胞外NAMPT（extracellular NAMPT，eNAMPT）、以及对心肌I／R的影响作一综述。趋向促进对NAMPT的作用及机制的了解，NAMPT有望成为治疗心肌I／R损伤的新靶点。

Background Nicotinamide phosphoribosyltransferas （NAMPT） is a rate-limiting enzyme in the biosynthesis of nicotinamide adenine dinucleotide （NAD）. NAMPT can exist within and outside cells, and their effects are not the same. NAMPT plays an important role in cardiovascular system, but the role of NAMPT in myocardial ischemic reperfusion is still controversial. Objective To further understand the role of NAMPT in cardiovascular system and myocardial ischemic/reperfusion（I/R）. Content Review the current researches on the souces of NAMPT and the potential cardiovascular effects, the effects of intracellular NAMPT （iNAMPT） and extracellular NAMPT （eNAMPT） on myocardial ischemic reperfusion. Trend Promote the understanding the role and mechanisms of NAMPT. It is expected to become a new target for the treatment of myocardial I/R injury.