维吾尔族与汉族支气管哮喘患儿血清IL-6、TNF-α与IgE水平比较

Comparison of serum IL-6,TNF-α and IgE levels in children with asthma in Uygur and Han populations

目的探讨并比较维吾尔族与汉族支气管哮喘患儿血清白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)及Ig E水平的变化及临床意义。方法采用双抗夹心酶联免疫法(ELISA)分别测定100例汉族及100例维族哮喘患儿急性发作期、缓解期血清中IL-6、TNF-α及Ig E水平,并以200例健康儿童为对照。结果维族与汉族哮喘急性发作期患儿血清中IL-6、TNF-α及Ig E水平均高于哮喘缓解期及对照组,缓解期3项指标仍高于对照组,差异有统计学意义(P<0.05)。维族对照组及哮喘缓解期、急性发作期IL-6水平均高于汉族,哮喘急性发作期与缓解期TNF-α低于汉族,急性发作期Ig E水平高于汉族,差异均有统计学意义(P<0.05)。结论维族及汉族支气管哮喘患儿不同时期血清中IL-6、TNF-α及Ig E水平存在差异,掌握其变化规律对指导两民族支气管哮喘患儿的诊断及治疗具有十分重要的临床价值。

Objective To investigate the changes and clinical significance of serum interleukin-6（ IL-6）,tumor necrosis factor-α（ TNF-α） and Ig E in Han and Uygur children suffered from asthma. Methods Enzyme linked immunosorbent assay（ ELISA） was used to detect the serum IL-6,TNF-α and Ig E levels in 200 healthy children（ as a normal control group）,100 Han children with asthma and 100 Uygur children with asthma. Results The levels of serum IL-6,TNF-α and Ig E of Han and Uygur children were higher than those in asthma remission and the control group（ P 〈0. 05）. The three indicators in remission stage group were higher than those in control group（ P 〈0. 05）. The IL-6 level in Uygur children was significantly higher than in Han group in acute attack stage,remission stage and control groups（ P 〈0. 05）; TNF-α was lower in acute attack group and remission stage group,and Ig E was higher in acute attack group,compared with those of Han children（ P 〈0. 05）. Conclusion There are differences in IL-6,TNF-α and Ig E levels at different stages of asthma between Uygur and Han children with asthma. This finding may have a very important clinical value in guiding the diagnosis and treatment of Uygur and Han children with bronchial asthma.