瑞鲍迪甙A对大鼠的致畸作用

Study on the Teratogenicity of Rebaudioside A in Wistar Rats

[目的]为进一步评价瑞鲍迪甙A的安全性积累资料。[方法]于大鼠孕7－17 d经口给予340、1 130和3 400 mg/kg b.w.剂量的瑞鲍迪甙A,观察母鼠和仔鼠的生长发育情况,研究瑞鲍迪甙A对大鼠的生殖毒性和胚胎毒性。[结果]各剂量瑞鲍迪甙A组孕鼠行为正常,无中毒和死亡情况。各剂量瑞鲍迪甙A组黄体数、着床数、活胎率、窝仔数及畸胎率、活胎仔畸形率及母体畸胎率等与正常对照组均无显著差异（P〉0.05）。[结论]瑞鲍迪甙A对大鼠无明显生殖毒性及胚胎毒性和致畸作用。

[ Objective ] The research aimed to provide materials for evaluating the safety of rebaudioside A futher. [ Method ] Rats were ad- ministrated with rebaudioside A at the doses of 340, 1 130 and 3 400 mg/kg b. w by gavage from the 7th day to the 17th day during the gestation. The growth and development laws of mother rats and baby rats were observed. And the reproductive toxicity and fetal toxicity of rebaudioside A to rats were studied. [ Result] Abnormal behaviours, toxic symptom and death were not found on tested rats. And there was no signifi- cant difference of the luteal count, implanted number and live fetus rate, litter size, abnormal fetus rate, abnormal rate of live fetus and materhal teratogenic rate in the groups of different doses of rebaudioside A had no significant difference with that on control group （ P 〉 0.05 ） . [ Conclusion ] Rebaudioside A had no obvious reproductive toxicity, embryo toxicity and teratogenic effect on Wistar rats.