霍奇金淋巴瘤诊治进展

Development of diagnosis and treatment for Hodgkin's lymphoma

霍奇金淋巴瘤(Hodgkin’s lymphoma,HL)是一种治愈率较高的恶性淋巴瘤。目前各研究组织提出的分期分级标准对风险调整治疗策略有重要的指导意义。近年来也不断推出低毒有效的联合化疗方案、正电子发射计算机断层扫描(PET)引导的放射治疗和靶向治疗药物。文章综述了HL的临床特征、鉴别诊断、经典型HL早期、进展期、复发难治阶段以及结节性淋巴细胞为主型HL的治疗进展,并强调关注各治疗阶段风险评估的重要性。

Hodgkin＇s lymphoma（HL）is a kind of highly curable malignant lymphoma.Staging criteria and risk stratifications from different organizations throughout the world are instructive for risk-adapted therapy.Scientific investigations over the recent years have provided insights into the low toxic and effective chemotherapy, positron emission tomography（PET）-based radiotherapy and new targeted drugs.This review demonstrates the clinical manifestations and differential diagnosis of HL, and the management of HL in the early-stage disease, advanced-stage disease, and at relapse,with a focus on the risk evaluation in each stage.