摘要
建立了一种可用于色谱分离条件快速优化的回归正交评价指标智能筛选法。以串行色谱响应函数作为色谱条件优化指标,利用回归正交试验设计建立回归模型,并通过最优解智能筛选程序对综合性优化指标进行筛选,最终实现色谱分离条件的最优化。结果表明:实验测定值与预测值的平均相对偏差为0.18%,优化结果理想。
This paper presents a method of regression evaluation index intelligent filter method (REIFM) for quick optimization of chromatographic separation conditions. The hierarchical chromatography response function was used as the chromatography-optimization index. The re- gression model was established by orthogonal regression design. The chromatography-optimiza- tion index was filtered by the intelligent filter program, and the optimization of the separation conditions was obtained. The experimental results showed that the average relative deviation between the experimental values and the predicted values was 0. 18% at the optimum and the optimization results were satisfactory.
出处
《色谱》
CAS
CSCD
北大核心
2015年第2期140-145,共6页
Chinese Journal of Chromatography
关键词
回归正交评价指标智能筛选法
串行色谱响应函数
回归正交试验设计
色谱条件的优化
高效液相色谱法
regression evaluation index intelligent filter method
hierarchical chromatographyresponse function
orthogonal regression design
chromatographic condition optimization
highperformance liquid chromatography ( HPLC )