回归正交评价指标智能筛选法用于色谱分离条件的快速优化

Regression evaluation index intelligent filter method for quick optimization of chromatographic separation conditions

建立了一种可用于色谱分离条件快速优化的回归正交评价指标智能筛选法。以串行色谱响应函数作为色谱条件优化指标,利用回归正交试验设计建立回归模型,并通过最优解智能筛选程序对综合性优化指标进行筛选,最终实现色谱分离条件的最优化。结果表明:实验测定值与预测值的平均相对偏差为0.18%,优化结果理想。

This paper presents a method of regression evaluation index intelligent filter method （REIFM） for quick optimization of chromatographic separation conditions. The hierarchical chromatography response function was used as the chromatography-optimization index. The re- gression model was established by orthogonal regression design. The chromatography-optimiza- tion index was filtered by the intelligent filter program, and the optimization of the separation conditions was obtained. The experimental results showed that the average relative deviation between the experimental values and the predicted values was 0. 18% at the optimum and the optimization results were satisfactory.