152株儿童腹泻志贺菌菌型分布及耐药性分析

Analysis on the distribution of 152 Shigella strains types and drug resistance in children

目的：了解儿童腹泻志贺菌菌型分布及耐药性情况,为临床合理用药提供指导。方法：收集2008-2012年唐山市妇幼保健院细菌性腹泻患儿粪便标本中分离出的志贺菌共152株,以纸片扩散法测定抗菌药物的敏感性。结果：152株志贺菌中以B群福氏志贺菌占优势,D群宋内志贺菌次之。药敏显示,志贺菌属对氨苄西林的耐药率达100.0%,对阿莫西林/克拉维酸、氨苄西林/舒巴坦高达82.2%、81.6%,对头孢噻肟、头孢曲松、头孢哌酮的耐药率分别为73.7%、76.3%、77%,而对头孢他啶、氨曲南耐的耐药率为30.3%、40.1%;亚胺培南、哌拉西林/他唑巴坦和头孢哌酮/舒巴坦的耐药率低,D群耐药率很低。结论：志贺氏菌其耐药性有所增加,提示临床合理用药。

Objective： To understand the distribution of Shigella strains types and drug resistance in children,provide guidance for clinical rational use of antibiotics. Methods： A total of 152 Shigella strains were separated from fecal specimens of children with bacterial diarrhea in this hospital from 2008 to 2012,disc diffusion method was used to detect the sensitivity of antibiotics. Results： Among 152 Shigella strains,the proportion of Shigella flexneri（ B group） was the highest,followed by Shigella sonnei（ D group）. The drug resistance of Shigella to ampicillin was 100. 0%; the drug resistances of Shigella to amoxicillin / clavulanic acid and ampicillin / sulbactam were as high as82. 2% and 81. 6%,respectively; the drug resistances of Shigella to cefotaxime,ceftriaxone and cefoperazone were 73. 7%,76. 3% and77%,respectively; the drug resistances of Shigella to ceftazidime and aztreonam were 30. 3% and 40. 1%,respectively; the drug resistances of Shigella to imipenem,piperacillin / tazobactam and cefoperazone / sulbactam were low,the drug resistance of D group was very low.Conclusion： The drug resistance of Shigella increases,which indicates that clinical rational use of antibiotics should be popularized.