EMs患者血清中IGF-I、VEGF水平变化及意义

Change of serum IGF-I and VEGF levels in the EMs patients

目的：观察胰岛素样生长因子-I（IGF-I）、血管内皮生长因子（VEGF）在子宫内膜异位症（EMs）患者血清中水平的变化及临床意义。方法：选取2012年3月-2013年5月间我院收治且经术后组织病理学诊断为宫内膜异位症的患者40例（观察组）,r-AFSⅠ-Ⅱ期19例,Ⅲ-Ⅳ期21例;设产同期收治并经术后组织病学诊断为卵巢成熟畸胎瘤的良性囊肿的患者40例（观察组）,于术前采两组患者空腹静脉血,采用酶联免疫吸附法（ELISA）检测两组患者血清中IGF-I、VEGF的水平,并分析其水平变化与EMs发病的关系。结果：观察组患者血清IGF-I、VEGF水平显著高于对照组（P〈0.05）;观察组患者r-AFS分期Ⅲ-Ⅳ期患者血清IGF-I、VEGF水平显著高于Ⅰ-Ⅱ期患者（P〈0.05）;经Pearson相关分析显示,EMs患者血清VEGF和IGF-I呈正相关性（r=0.508,P〈0.05）。结论：IGF-I、VEGF在EMs发病过程中起协助作用,且与疾病严重程度呈正相关,以IGF-I、VEGF为治疗靶点来阻断EMs病灶新生血管的生成,可能成为治疗EMs的新途径。

Objective： To observe the change of serum insulin-like growth factor I （IGF-I） and vascular endothelial growth factor （VEGF） levels in the endometriosis （EMs） patients and their clinical significance. Methods： A total of 40 patients confirmed with EMs by postoperative histopathology who were admitted in our hospital from March, 2012 to May, 2013 were enrolled in our study and served as the observation group, among which 19 cases were at the r-AFS Ⅰ-Ⅱ stage, and 21 cases were at the Ⅲ-Ⅳ stage. While a total of 40 patients diagnosed with mature ovary teratoma by postoperative histopathology were served as the eontro~ group. The {asting venous blood was taken from the patients in the two groups before opera- tion. ELISA was used to detect the serum IGF-I and VEGF levels and the relationship between the level change and EMs was analyzed. Results： The serum IGF-I and VEGF levels in the observation group were significantly higher than those in the control group （P〈0.05） ; the serum IGF-I and VEGF levels in the observation group at the Ⅲ-Ⅳ stage were significantly higher than those at the Ⅰ-Ⅱ stage （P〈0.05）. Pearson correlation analysis showed that VEGF was positively correlated with IGF-I in the EMs patients （r=0. 508,P〈0.05）. Conclusions： IGF I and VEGF play an assistant role in the pathogenesis of EMs and are positively correlated with the severity of the disease. IGF-I and VEGF can be used as the therapeutic targets to block the generation of new vessels in the EMs lesions, which may become a new path to treat EMs.