对发生药物不良反应AIDS患者服药依从性的干预研究

The effectiveness of individualized management on the medication compliance in AIDS patients with adverse drug reactions

目的探讨个体化管理对提高AIDS患者抗病毒治疗期间发生药物不良反应后服药依从性的效果。方法将72例发生药物不良反应的AIDS患者按其就诊时间先后分为实验组和对照组。实验组36例实施个体化管理,主要通过电话、微信或短信、面谈及QQ聊天方式,对患者进行为期1年的16次随访,随访内容包括抗病毒治疗相关知识宣教、遵医行为的技巧、心理干预。对照组35例给予常规服药指导。持续随访12个月后,根据抗病毒治疗随访及用药登记表和自制表格对患者进行依从性效果评估。结果实验组患者服药依从性明显好于对照组,就医失落率明显低于对照组,差异均具有统计学意义(P<0.05)。结论实施个体化管理可明显提高AIDS患者在抗病毒治疗过程中出现不良反应后的服药依从性,减少就医失落,从而保证抗病毒治疗的顺利进行。

Objective To evaluate the effectiveness of individualized management on the medication adherence in AIDS patients with adverse drug reactions. Methods Seventy-two AIDS patients with adverse drug reactions were divided into two groups. The 36 patients in the experimental group received individualized management. They were followed up for 16 times during 1 year through telephone,messages or wechat,face-to-faee interviews and QQ chat. The follow-up focused on drug therapy guldance,adherence education and psychological intervention. The 35 patients in the control group received routine medication guide. Their compliance was assessed using the tables of anti-viral treatment registration and a self-designed questionnaire. Results The medication adherence was significantly higher and the loss rate of treatment was significantly lower in the experimental group than those in the control group（P〈 0.05）. Conclusion Individualized management can improve the medication adherence in AIDS patients with adverse drug reactions and reduce the incidence of medical loss,which successfully contributes to antiviral therapy.