血浆催乳素水平与绝经前乳腺癌危险性的关系评估

Relationship between plasma prolactin concentration and risk of breast cancer among premenopausal women

目的：评估血浆催乳素（PRL）水平与绝经前女性乳腺癌危险性的关系。方法：采用放射免疫法测定65例绝经前女性乳腺癌患者（病例组）和65例匹配对照者（对照组）的血浆PRL水平,条件logistic回归分析血浆PRL水平与绝经前乳腺癌危险性的关系。根据肿瘤的临床病理特征对病例组再进行分组,评价血浆PRL水平与乳腺癌各亚组危险性的关系。结果：病例组血浆PRL水平显著高于对照组（P〈0.01）。血浆PRL水平上四分位数相比下四分位数的调整OR（95%CI）为1.54（0.84-4.07）,趋势P=0.031;PRL与绝经前乳腺癌危险性的关系在雌激素受体阳性的肿瘤中稍增强,但不随肿瘤大小、病理类型、肿瘤分级、淋巴结转移情况而变化。结论：血浆PRL水平与绝经前女性乳腺癌的危险性呈正相关,尤其是雌激素受体阳性的乳腺癌患者。

Objective： To estimate the association of plasma prolactin（ PRL） concentration with the risks of breast cancer among premenopausal women. Methods： The concentration of plasma PRL was measured in 65 premenopausal women with breast cancer and65 matched control subjects by radioimmunoassay. The relations between the plasma PRL concentration and the breast cancer in premenopausal women were observed using conditional logistic regression analysis. All the cases were grouped according to the pathological features; the association of the level of PRL and the risk of breast cancer for different sub-groups were evaluated. Results：The plasma PRL concentration of the case group was significantly higher than that of the control group. Increased risk of breast cancer was positively related with the elevated plasma concentration of PRL（ adjusted odds ratio [OR]for the highest versus the lowest quartile= 1. 54,95% confidence interval [95% CI]= 0. 84- 4. 07,Ptrend = 0. 031）. The concentration of plasma PRL increased modestly in estrogen receptor positive carcinomas but did not change with the tumor size,grade or lymph node status. Conclusions： The results suggest that high plasma concentration of PRL is positively related with the breast cancer,especially estrogen receptor positive carcinomas among premenopausal women.