国外天然产物化学成分实物库及数据库建设概况

Status of libraries and databases for natural products at abroad

天然产物是新药发现的重要源泉,天然产物化学成分实物库和数据库的建设对天然产物的研究与开发具有重要意义。目前国外建设的小分子化合物库多为合成或组合合成分子,天然产物实物获取较困难。在信息数据库建设方面由于使用标准不同,信息不统一,开发规范、实用、智能型、综合型的大规模天然产物数据库还存在一定困难。该文就目前国外可以公开查询到的有关天然产物的实物库及数据库建设情况进行了概述和分析,以期对天然产物研究与开发,特别是天然产物化学成分实物库和数据库的建设提供参考。

For natural products are one of the important sources for drug discovery, libraries and databases of natural products are significant for the development and research of natural products. At present, most of compound libraries at abroad are synthetic or com- binatorial synthetic molecules, resulting to access natural products difficult ; for information of natural products are scattered with differ- ent standards, it is difficuh to construct convenient, comprehensive and large-scale databases for natural products. This paper reviewed the status of current accessing libraries and databases for natural products at abroad and provided some important information for the development of libraries and database for natural products.