原发性精囊透明性细胞癌1例报告并文献复习

One case report of primary clear cell carcinoma of the seminal vesicle and literature review

目的:探讨原发性精囊透明细胞癌的临床表现、病理特征及诊断治疗。方法:对我院收治的1例原发性精囊透明细胞癌患者的临床资料进行回顾分析,并复习相关文献。结果:本例患者因反复血精2年入院,术前经影像学及精囊镜活检证实为右侧精囊原发透明细胞癌,免疫组织化学检查示PSA-,CK7-,CD125-,CD20-,RCC+,CD10+,EMA+,行开放性膀胱前列腺精囊切除术、盆腔淋巴结清扫术及回肠膀胱术。术后随访1年,未见肿瘤复发及肾脏占位病变。结论:原发性精囊癌病理分型为透明细胞癌类型极为罕见,手术为其主要治疗方法,需达到肿瘤切缘阴性,术后是否行抗雄激素治疗或放化疗等辅助治疗尚存在争议。

Objective： To investigate the clinical manifestation, pathological characteristics, diagnosis and treatment of primary clear cell carcinoma of seminal vesicle. Method： The clinical data of one case diagnosed as primary clear cell carcinoma of seminal vesicle was collected retrospectively and the related literature was reviewed. Result A 62-year-old patient with recurrent hemospermia for two years was admitted to our hospital, and was diagnosed as primary seminal vesicle clear cell carcinoma by radiological image and seminal vesiculoscopy biop- sy. The results of immunohistochemical staining were PSA-, CK7-, CD125-, CD20-, RCC＋, CD10＋, EMA＋. The patients underwent open cystoprostatovesiculectomy with pelvic lymph nodes dissection and urinary diversion. The patient was followed up for 12 months and there was no recurrence or renal mass occurred. Conclusion： Primary seminal vesicle clear cell carcinoma is a rare pathological type of primary seminal vesicle tumor, and the mainstay of therapy for this carcinoma was to achieve a negative margin resection. Whether it is valuable to receive antiandrogenic therapy, chemotherapy or radiotherapy is still in controversy.