MicroRNAs in breast cancer: oncogene and tumor suppressors with clinical potentia

MicroRNA在乳腺癌发展过程中的作用机制及临床应用分析(英文)

MicreRNAs （miRs） are small single-stranded RNA molecules, which function as key negative regulators of post-transcriptional modulation in almost all biological processes. Abnormal expression of microRNAs has been ob- sewed in various types of cancer including breast cancer. Great efforts have been made to identify an association between microRNA expression profiles and breast cancer, and to understand the functional role and molecular mechanism of aberrant-expressed microRNAs. As research progressed, ＇oncogenic microRNAs＇ and ＇tumor sup- pressive microRNAs＇ became a focus of interest. The potential of candidate microRNAs from both intercellular （tissue） and extraceUular （serum） sources for clinical diagnosis and prognosis was revealed, and treatments involving microRNA achieved some amazing curative effects in cancer disease models. In this review, advances from the most recent studies of microRNAs in one of the most common cancers, breast cancer, are highlighted, especially the functions of specifically selected microRNAs. We also assess the potential value of these microRNAs as diagnostic and prognostic markers, and discuss the possible development of microRNA-based therapies.

搜集已报道的在乳腺癌发生发展过程中有重要作用的micro RNA信息,结合相关肿瘤模型的实验数据,评估micro RNA在乳腺癌诊断和治疗方面的应用前景。以"癌基因"和"癌抑制基因"为分类依据,全面地总结归纳乳腺癌相关micro RNA的功能和作用机制,进一步从临床诊断标记物和治疗靶点的层面分析micro RNA的潜在临床应用价值。表1和2总结了micro RNA参与乳腺癌发展过程的具体事件及其调控的靶基因。同时,本文还深入探讨micro RNA作为临床诊断标记物及治疗靶点的可行性,揭示已有研究的不足之处,为今后的相关工作方向提供一些建议。